通过表面免疫球蛋白对小鼠B细胞的调节。I. 诱导同种异型特异性增殖的单克隆抗δ抗体。
Regulation of murine B cells through surface immunoglobulin. I. Monoclonal anti-delta antibody that induces allotype-specific proliferation.
作者信息
Zitron I M, Clevinger B L
出版信息
J Exp Med. 1980 Nov 1;152(5):1135-46. doi: 10.1084/jem.152.5.1135.
Abstract
We describe the identification of a monoclonal antibody that recognizes a determinant on the delta chain of mice of the Iga, allotype groups. The monoclonal Ig in soluble form induces allotype-specific proliferation by splenic B lymphocytes from normal animals of these haplotypes. Spleen cells from mice bearing the X-linked defect of CBA/N mice fail to respond, although they bear the determinant. Proliferation is independent of T lymphocytes. The data indicate a direct triggering function for sIgD.
摘要
我们描述了一种单克隆抗体的鉴定，该抗体识别Iga同种异型组小鼠δ链上的一个决定簇。可溶性形式的单克隆Ig可诱导这些单倍型正常动物脾脏B淋巴细胞发生同种异型特异性增殖。携带CBA/N小鼠X连锁缺陷的小鼠脾脏细胞虽然带有该决定簇，但无反应。增殖不依赖于T淋巴细胞。这些数据表明sIgD具有直接触发功能。
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