Department of Internal Medicine, Marshfield Clinic Health System, Marshfield, WI.
Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, WI.
Clin Med Res. 2020 Aug;18(2-3):89-94. doi: 10.3121/cmr.2020.1548. Epub 2020 Jun 24.
Aspirin has demonstrated a clear benefit in secondary prevention of coronary syndrome, while aspirin's effect in primary prevention is unclear. This report will explore the role of aspirin as primary prevention for various vascular events. It strives to provide a clear guide for clinicians on whether or not to prescribe aspirin for their patients for primary prevention. Current guidelines and recent trials failed to show clear benefit against primary prevention, with risks outweighing benefits in moderate to high risk patients. A thoughtful discussion between patients and their doctors should be conducted before beginning aspirin use. More studies are needed to gain a better understanding of aspirin use in primary prevention.
阿司匹林在冠心病二级预防中已证实明确获益，而阿司匹林在一级预防中的作用尚不明确。本报告将探讨阿司匹林作为各种血管事件一级预防的作用。旨在为临床医生是否为患者开具阿司匹林进行一级预防提供明确指导。目前的指南和近期的试验未能显示出一级预防的明确获益，中高危患者风险大于获益。在开始使用阿司匹林之前，患者及其医生应进行深思熟虑的讨论。需要更多的研究来更好地了解阿司匹林在一级预防中的应用。
