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阿司匹林的故事——从柳树到神奇药物。

The aspirin story - from willow to wonder drug.

作者信息

Desborough Michael J R, Keeling David M

机构信息

NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK.

Oxford Clinical Research in Transfusion Medicine, Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.

出版信息

Br J Haematol. 2017 Jun;177(5):674-683. doi: 10.1111/bjh.14520. Epub 2017 Jan 20.

Abstract

The story of the discovery of aspirin stretches back more than 3500 years to when bark from the willow tree was used as a pain reliever and antipyretic. It involves an Oxfordshire clergyman, scientists at a German dye manufacturer, a Nobel Prize-winning discovery and a series of pivotal clinical trials. Aspirin is now the most commonly used drug in the world. Its role in preventing cardiovascular and cerebrovascular disease has been revolutionary and one of the biggest pharmaceutical success stories of the last century.

摘要

阿司匹林的发现历程可以追溯到3500多年前,当时柳树皮被用作止痛和解热药物。这一历程涉及一位牛津郡的牧师、一家德国染料制造商的科学家、一项诺贝尔奖获奖发现以及一系列关键的临床试验。如今,阿司匹林是世界上最常用的药物。它在预防心脑血管疾病方面所起的作用具有革命性,是上世纪制药领域最成功的案例之一。

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