Moser F G, Hilal S K, Abrams G, Bello J A, Schipper H, Silver A J
Neurological Institute, New York, NY 10032.
AJR Am J Roentgenol. 1988 Apr;150(4):903-9. doi: 10.2214/ajr.150.4.903.
Eleven obese young women with idiopathic pseudotumor cerebri were studied with high-field-strength (1.5 T) MR imaging to demonstrate increased water content in the brains of such patients. Heavily T2-weighted studies were obtained for 10 patients, and balanced (long TRs, short TEs, spin density, proton density) pulse sequences were obtained for four patients. We examined the studies of morphologically normal periventricular white matter and developed a white matter water index to determine if a slight increase in signal was present that could be ascribed to low levels of edema. Comparison was made to an age-matched control group. We also examined five patients with sodium MR imaging. Two of the 11 patients had focal areas of increased signal in their periventricular white matter. Presumably, these are areas of increased edema above the background that could not be detected on the CT scan. The white matter water index for the normal controls was an average of 0.479 (+/- 0.015), while that of the pseudotumor cerebri group was 0.520 (+/- 0.016). This indicates an increase in the white matter water signal. We believe this represents a diffuse low level of edema. These findings are consistent with previous estimates of the increase in brain water in patients with idiopathic pseudotumor cerebri. The patients with focally abnormal proton studies demonstrated similar abnormalities on their sodium studies.
对11名患有特发性假脑瘤的肥胖年轻女性进行了高场强（1.5T）磁共振成像研究，以证明此类患者大脑中的含水量增加。对10名患者进行了重T2加权研究，对4名患者进行了平衡（长TR、短TE、自旋密度、质子密度）脉冲序列研究。我们检查了形态学正常的脑室周围白质的研究，并制定了白质水指数，以确定是否存在可归因于低水平水肿的信号轻微增加。与年龄匹配的对照组进行了比较。我们还对5名患者进行了钠磁共振成像检查。11名患者中有2名在脑室周围白质出现局灶性信号增强区域。据推测，这些是高于背景的水肿增加区域，在CT扫描上无法检测到。正常对照组的白质水指数平均为0.479（±0.015），而假脑瘤组的白质水指数为0.520（±0.016）。这表明白质水信号增加。我们认为这代表弥漫性低水平水肿。这些发现与先前对特发性假脑瘤患者脑水量增加的估计一致。质子研究局灶性异常的患者在钠研究中也表现出类似的异常。
