Department of Veterinary Internal Medicine, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju, 61186, Korea.
Department of Veterinary Laboratory Medicine, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, Korea.
J Vet Med Sci. 2020 Aug 28;82(8):1130-1137. doi: 10.1292/jvms.20-0125. Epub 2020 Jul 23.
The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagles as healthy controls were included. All dogs underwent physical examination, systemic blood pressure measurement, complete blood cell count, and plasma biochemistry analyses. Frozen serum was used for SDMA and CysC analyses. Data analysis was performed using Kruskal Wallis, Pearson's correlation, Bland-Altman plots, and receiver operating characteristic curve. SDMA and CysC levels were significantly higher in patients with CKD at various International Renal Interest Society (IRIS) stages than in the healthy controls. In particular, CysC level was the only biomarker that could indicate the earliest stage of CKD (IRIS stage I). Similar to these results, CysC level showed better sensitivity and specificity compared to the other biomarkers in early CKD dogs.
本研究旨在确定血清对称二甲基精氨酸（SDMA）和胱抑素 C（CysC）水平是否可作为犬早期肾功能障碍的更准确标志物。本研究纳入了 41 只患有慢性肾病（CKD）且临床稳定的患犬和 10 只比格犬作为健康对照组。所有犬均接受了体格检查、全身血压测量、全血细胞计数和血浆生化分析。使用冷冻血清进行 SDMA 和 CysC 分析。采用 Kruskal-Wallis、Pearson 相关性、Bland-Altman 图和受试者工作特征曲线进行数据分析。不同国际肾脏学会（IRIS）分期的 CKD 患者的 SDMA 和 CysC 水平明显高于健康对照组。特别是，CysC 水平是唯一可以指示 CKD 最早阶段（IRIS 分期 I）的生物标志物。与这些结果类似，CysC 水平在早期 CKD 犬中比其他生物标志物具有更好的敏感性和特异性。
