Departments of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Departments of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Korean J Gastroenterol. 2020 Jun 25;75(6):356-361. doi: 10.4166/kjg.2020.75.6.356.
Autoimmune pancreatitis (AIP) is a rare and unique type of chronic pancreatitis. The prognosis of AIP, particularly when associated with pancreatic cancer or a related malignancy, is not known. Only a few cases, where metachronous pancreas-related cancer developed during follow-up, have been reported. Most of these patients either underwent surgery or steroid therapy. This paper reports a case of a 66-year-old woman with untreated type I AIP who developed peritoneal carcinomatosis more than 2 years later. Initially, the patient had a markedly elevated serum IgG4 level and a diffuse, infiltrative mass-like lesion in the pancreatic head, in which the biopsy results were consistent with type I AIP. The patient was not treated with steroids because of a cerebellar infarction. Twenty-eight months after the diagnosis of AIP, peritoneal carcinomatosis developed without noticeable changes in the pancreas from the initial findings.
自身免疫性胰腺炎（AIP）是一种罕见且独特的慢性胰腺炎类型。AIP 的预后，特别是当与胰腺癌或相关恶性肿瘤相关时，尚不清楚。仅报道了少数几例在随访期间发生异时性胰腺相关癌症的病例。这些患者大多接受了手术或类固醇治疗。本文报告了一例 66 岁女性，患有未经治疗的 I 型 AIP，2 年多后发展为腹膜癌病。最初，患者血清 IgG4 水平显著升高，胰头部弥漫性浸润性肿块样病变，活检结果符合 I 型 AIP。由于小脑梗死，患者未接受类固醇治疗。在诊断为 AIP 28 个月后，出现腹膜癌病，而初始发现的胰腺没有明显变化。
