Department of Radiology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Department of Radiology and Imaging, Medical College of Georgia, 1120 15th Street BA-1411, Augusta, GA, 30912, USA.
Abdom Radiol (NY). 2020 May;45(5):1371-1386. doi: 10.1007/s00261-019-02210-0.
Autoimmune pancreatitis (AIP) is an inflammatory process of the pancreas that occurs most commonly in elderly males and clinically can mimic pancreatic adenocarcinoma and present with jaundice, weight loss, and abdominal pain. Mass-forming lesions in the pancreas are seen in the focal form of AIP and both clinical and imaging findings can overlap those of pancreatic cancer. The accurate distinction of AIP from pancreatic cancer is of utmost importance as it means avoiding unnecessary surgery in AIP cases or inaccurate steroid treatment in patients with pancreatic cancer. Imaging concomitantly with serological examinations (IgG4 and Ca 19-9) plays an important role in the distinction between these entities. Characteristic extra-pancreatic manifestations as well as favorable good response to treatment with steroids are characteristic of AIP. This paper will review current diagnostic parameters useful in differentiating between focal AIP and pancreatic adenocarcinoma.
自身免疫性胰腺炎（AIP）是一种胰腺炎症性疾病，最常见于老年男性，临床上可模拟胰腺腺癌，并表现为黄疸、体重减轻和腹痛。胰腺的肿块形成病变见于 AIP 的局灶性形式，临床和影像学表现可与胰腺癌重叠。准确地区分 AIP 与胰腺癌至关重要，因为这意味着在 AIP 病例中避免不必要的手术，或在患有胰腺癌的患者中避免不准确的类固醇治疗。影像学与血清学检查（IgG4 和 CA19-9）同时进行在这些实体之间的区分中起着重要作用。特征性的胰外表现以及对类固醇治疗的良好反应是 AIP 的特征。本文将回顾目前用于区分局灶性 AIP 和胰腺腺癌的有用诊断参数。
