Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.
Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, United States.
Am J Physiol Heart Circ Physiol. 2024 Mar 1;326(3):H832-H844. doi: 10.1152/ajpheart.00532.2023. Epub 2024 Feb 2.
Cardiac aging is a multifaceted process that encompasses structural and functional alterations culminating in heart failure. As the elderly population continues to expand, there is a growing urgent need for interventions to combat age-related cardiac functional decline. Noncoding RNAs have emerged as critical regulators of cellular and biochemical processes underlying cardiac disease. This review summarizes our current understanding of how noncoding RNAs function in the heart during aging, with particular emphasis on mechanisms of RNA modification that control their activity. Targeting noncoding RNAs as potential novel therapeutics in cardiac aging is also discussed.
心脏衰老（Cardiac aging）是一个多方面的过程，包括结构和功能的改变，最终导致心力衰竭（heart failure）。随着老年人口的持续增长，人们迫切需要干预措施来对抗与年龄相关的心脏功能下降。非编码 RNA 已成为调控心脏疾病相关细胞和生化过程的关键因素。本综述总结了我们目前对非编码 RNA 在衰老心脏中发挥作用的理解，特别强调了控制其活性的 RNA 修饰机制。还讨论了将非编码 RNA 作为心脏衰老潜在新型治疗靶点的可能性。
