[乙卡嗪（乙吗噻嗪的二乙基类似物）对心脏相依赖副交感神经效应的影响]
[Influence of ethacizin (the diethyl analog of ethmozine) on phase-dependent parasympathetic effects on the heart].
作者信息
Kopylova G N, Krupnova E P
出版信息
Biull Eksp Biol Med. 1988 Mar;105(3):298-300.
The influence of ethacizin (a diethylamine analog of ethmozine) (1.10(-7)-1.10(-6) g/ml) upon the phase-dependent chronotropic parasympathetic effects was studied on the perfused frog heart. The vagolytic influence of ethacizin (5.10(-7) and 1.10(-6) g/ml) was detected; the concentration of 1.10(-7) g/ml was found ineffective. The vagolytic effect consisted of a decreased maximum of phase-dependent effect, reduced latency and time required for the manifestation of the maximum increase. The period of inhibitory vagal stimulus effectiveness did not change significantly.
在离体蛙心标本上研究了乙卡嗪（乙胺嗪的二乙胺类似物）（1.10⁻⁷ - 1.10⁻⁶ g/ml）对依时性副交感神经变时作用的影响。检测到乙卡嗪（5.10⁻⁷ 和 1.10⁻⁶ g/ml）具有抗迷走神经作用；发现 1.10⁻⁷ g/ml 的浓度无效。抗迷走神经作用包括依时性作用的最大效应降低、潜伏期缩短以及达到最大增加所需的时间缩短。抑制性迷走神经刺激的有效持续时间无明显变化。
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