Acute lymphoblastic leukemia with a unique rearrangement between chromosomes 4 and 11.
作者信息
O'Malley D P, Kulkarni R, Oaks M K, Higgins J V
机构信息
Department of Pathology, E. W. Sparrow Hospital, Lansing, Michigan 48909-9986.
出版信息
Cancer Genet Cytogenet. 1988 Apr;31(2):291-4. doi: 10.1016/0165-4608(88)90231-2.
PMID:3258177
Abstract
A case of pre-B cell acute lymphoblastic leukemia (pre-B ALL) with a dir ins(11;4)(q23;q21q31) chromosome rearrangement is presented. The patient's clinical findings and history were similar to those described for the t(4;11)(q21;q23) subgroup of childhood ALL. These findings suggest that the interfacing of the distal breakpoint at band 4q21 to the proximal breakpoint of band 11q23 represents the primary cytogenetic change observed in this subgroup of ALL.
摘要
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