儿童急性淋巴细胞白血病中1号和9号染色体之间的易位。
Translocation between chromosomes 1 and 9 in childhood acute lymphoblastic leukemia.
作者信息
Ohyashiki K, Kocova M, Ohyashiki J H, Ryan D H, Rowe J M, Sandberg A A
出版信息
Cancer Genet Cytogenet. 1986 Mar 1;21(1):5-10. doi: 10.1016/0165-4608(86)90196-2.
A case of a non-T, non-B acute lymphoblastic leukemia with a translocation between chromosomes #1 and #9 is described. The breakpoints in these chromosomes were determined to be at bands 1q23 and 9p22, respectively. The breakpoint in chromosome #1 was at the same site as that in a subgroup of acute lymphoblastic leukemia with t(1;19), and the breakpoint in #9 was the same as that in t(9;11)(p22;q23) in acute monoblastic leukemia. We discuss the possible association between these chromosome bands (1q23, 9p22, 11q23, and 19p13) and the morphologic features of the leukemic cells. The breakpoint in chromosome band 1q23 may be specifically associated with acute lymphoblastic leukemia.
本文描述了一例非T、非B急性淋巴细胞白血病病例，该病例存在1号与9号染色体之间的易位。这些染色体上的断点分别确定在1q23带和9p22带。1号染色体上的断点与伴有t(1;19)的急性淋巴细胞白血病亚组中的断点位于同一位置，9号染色体上的断点与急性单核细胞白血病中t(9;11)(p22;q23)的断点相同。我们讨论了这些染色体带（1q23、9p22、11q23和19p13）与白血病细胞形态学特征之间可能存在的关联。染色体带1q23上的断点可能与急性淋巴细胞白血病存在特异性关联。
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