Li Yanxuan, Zhu Zili, Chen Jie, Zhang Minming, Yang Yunjun, Huang Peiyu
Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Aging Neurosci. 2020 Jun 5;12:161. doi: 10.3389/fnagi.2020.00161. eCollection 2020.
The imbalance between the production and clearance of alpha-synuclein and its consequent accumulation plays a pivotal role in the pathogenesis of Parkinson's disease (PD). The diminished clearance of alpha-synuclein may be partly attributable to impaired interstitial fluid, which can be reflected by the extent of dilated perivascular space (dPVS). We studied the association between dPVS and dopamine neuronal degeneration. We screened 71 healthy controls (HCs) and 88 patients from the Parkinson Progression Markers Initiative (PPMI) database. The dPVS was evaluated in different brain regions on axial T2-weighted images, and dopamine transporter (DAT) imaging data was used to elucidate the extent of dopaminergic neuronal degeneration. Patients with PD were further divided into two groups (SN + PD and SN - PD groups) according to whether dPVS was observed in the substantia nigra (SN). DAT uptake values and clinical scales were compared between the patients with PD and HCs and against dPVS scores. We also investigated the correlation between baseline dPVS scores and longitudinal DAT changes. Relative to the HCs, patients with PD had more dPVS in the SN and basal ganglia (BG). PD patients with dPVS in the SN region exhibited greater expression of tau protein in cerebrospinal fluid ( = 0.038) and a trend towards decreased DAT binding ( = 0.086) relative to those without SN dPVS. No correlations were found between dPVS scores and DAT uptake values or between dPVS scores and longitudinal DAT changes. The dPVS in the SN of patients with PD may reflect the degeneration of dopaminergic neurons.
α-突触核蛋白生成与清除之间的失衡及其随后的积累在帕金森病（PD）的发病机制中起关键作用。α-突触核蛋白清除减少可能部分归因于间质液受损，这可通过血管周围间隙扩张（dPVS）的程度来反映。我们研究了dPVS与多巴胺能神经元变性之间的关联。我们从帕金森病进展标志物倡议（PPMI）数据库中筛选了71名健康对照者（HCs）和88名患者。在轴向T2加权图像上评估不同脑区的dPVS，并使用多巴胺转运体（DAT）成像数据来阐明多巴胺能神经元变性的程度。根据黑质（SN）是否存在dPVS，将PD患者进一步分为两组（SN + PD组和SN - PD组）。比较了PD患者与HCs之间以及与dPVS评分相关的DAT摄取值和临床量表。我们还研究了基线dPVS评分与DAT纵向变化之间的相关性。相对于HCs，PD患者在SN和基底神经节（BG）中有更多的dPVS。与无SN dPVS的患者相比，SN区域存在dPVS的PD患者脑脊液中tau蛋白表达更高（P = 0.038），且DAT结合有降低趋势（P = 0.086）。未发现dPVS评分与DAT摄取值之间或dPVS评分与DAT纵向变化之间存在相关性。PD患者SN中的dPVS可能反映了多巴胺能神经元的变性。
