Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine 310000, Hangzhou, China; Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University 325000, Wenzhou, China.
Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine 310000, Hangzhou, China.
Psychiatry Res Neuroimaging. 2020 Feb 29;296:111029. doi: 10.1016/j.pscychresns.2019.111029. Epub 2019 Dec 28.
Parkinson's disease (PD) pathology may damage emotion circuit and cause depression. We investigated whether the neural basis of depressive symptoms varies at different PD stages. Seventy-six healthy controls (HC) and 98 PD patients (divided into early and middle stage groups) underwent brain magnetic resonance imaging (MRI) and general neuropsychological tests. Voxel-based morphometry and tract-based analysis were used to study the association between brain structural alterations and the Hamilton Depression Scale 17 Item (HAMD-17) scores in different groups. Comparing with HC group, PD patients showed widespread brain alterations in both gray and white matter. The HAMD-17 scores were positively correlated with GM volume in the right pre-central gyrus of early PD patients. In the middle stage group, HAMD-17 scores were positively correlated with GM volume in midbrain and right superior temporal gyrus, and negatively associated with GM volume in left anterior cingulate and superior frontal gyrus. In white matter analysis, The HAMD-17 scores were positively correlated with fractional anisotropy value of the bilateral inferior fronto-occipital fasciculus in the early stage group, but not the middle stage group. We concluded that the neural basis of depressive symptoms might be distinct in different stages of PD, implying the need for differential treatments.
帕金森病（PD）病理学可能会损害情绪回路并导致抑郁。我们研究了抑郁症状的神经基础是否在不同的 PD 阶段有所不同。76 名健康对照者（HC）和 98 名 PD 患者（分为早期和中期组）接受了脑磁共振成像（MRI）和一般神经心理学测试。基于体素的形态学和基于束的分析用于研究不同组中脑结构改变与汉密尔顿抑郁量表 17 项（HAMD-17）评分之间的关联。与 HC 组相比，PD 患者在灰质和白质中均表现出广泛的脑改变。HAMD-17 评分与早期 PD 患者右侧中央前回的 GM 体积呈正相关。在中期组中，HAMD-17 评分与中脑和右侧颞上回的 GM 体积呈正相关，与左前扣带回和额上回的 GM 体积呈负相关。在白质分析中，HAMD-17 评分与早期组双侧下额枕束的各向异性分数值呈正相关，但在中期组中则无相关性。我们得出结论，抑郁症状的神经基础在 PD 的不同阶段可能存在差异，这表明需要进行差异化治疗。
