Michel Jennifer, Abd Rani Nur Zahirah, Husain Khairana
Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Pharmacol. 2020 Jun 5;11:852. doi: 10.3389/fphar.2020.00852. eCollection 2020.
Cardiovascular diseases are one of the most prevalent diseases worldwide, and its rate of mortality is rising annually. In accordance with the current condition, studies on medicinal plants upon their activity on cardiovascular diseases are often being encouraged to be used in cardiovascular disease management, due to the availability of medicinal values in certain dedicated plants. This review was conducted based on two plant families, which are Asteraceae and Lamiaceae, to study on their action in cardiovascular disease relieving activities, to review the relationship between the phytochemistry of Asteraceae and Lamiaceae families and their effect on cardiovascular diseases, and to study their toxicology. The medicinal plants from these plant family groups are collected based on their effects on the mechanisms that affect the cardiovascular-related disease which are an antioxidant activity, anti-hyperlipidemic or hypocholesterolemia, vasorelaxant effect, antithrombotic action, and diuresis effect. In reference to various studies, the journals that conducted or experiments, which were used to prove the specific mechanisms, are included in this review. This is to ensure that the scientific value and the phytochemicals of the involved plants can be seen based on their activity. As a result, various plant species from both Asteraceae and Lamiaceae plant family have been identified and collected based on their study that has proven their effectiveness and uses in cardiovascular diseases. Most of the plants have an antioxidant effect, followed by anti-hyperlipidemia, vasorelaxant, antithrombotic, and diuretic effect from the most available to least available studies, respectively. These are the mechanisms that contribute to various cardiovascular diseases, such as heart attack, stroke, coronary heart disease, and hypertension. Further studies can be conducted on these plant species by identifying their ability and capability to be developed into a new drug or to be used as a medicinal plant in treating various cardiovascular diseases.
心血管疾病是全球最普遍的疾病之一，其死亡率逐年上升。根据目前的情况，由于某些特定植物具有药用价值，对药用植物在心血管疾病方面活性的研究经常被鼓励用于心血管疾病管理。本综述基于两个植物科，即菊科和唇形科，研究它们在缓解心血管疾病方面的作用，回顾菊科和唇形科植物化学与它们对心血管疾病影响之间的关系，并研究它们的毒理学。这些植物科组中的药用植物是根据它们对影响心血管相关疾病机制的作用收集的，这些机制包括抗氧化活性、抗高血脂或降胆固醇、血管舒张作用、抗血栓形成作用和利尿作用。参考各种研究，本综述纳入了进行相关实验以证明特定机制的期刊。这是为了确保基于其活性可以看出所涉及植物的科学价值和植物化学物质。结果，根据已证明其在心血管疾病中的有效性和用途的研究，已鉴定并收集了菊科和唇形科植物家族的各种植物物种。大多数植物具有抗氧化作用，其次是抗高血脂、血管舒张、抗血栓形成和利尿作用，从现有研究最多到最少依次排列。这些是导致各种心血管疾病的机制，如心脏病发作、中风、冠心病和高血压。通过确定这些植物物种开发成新药或用作治疗各种心血管疾病的药用植物的能力，可以对它们进行进一步研究。
