Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
School of Traditional Medicine, Babol University of Medical Sciences, Babol, Islamic Republic of Iran.
J Thromb Thrombolysis. 2018 Jan;45(1):158-179. doi: 10.1007/s11239-017-1580-3.
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties. This study reviewed the pharmacological effects of medicinal plants mentioned in PM literature for blood clot management in light of current knowledge. Plants mentioned in PM for management of blood clot belong to 12 families in which Apiaceae, Lamiaceae and Compositae were the most repeated ones. Among the proposed plants Allium sativum, Rosmarinus officinalis, Boswellia serrata, Sesamum indicum, Matricaria chamomilla and Carthamus tinctorius have been the most researched plants in modern antithrombotic studies while for some plants such as Helichrysum stoechas, Dracocephalum kotschi, Carum carvi, Bunium persicum and Lagoecia cuminoides no evidence could be found. One of the interesting notes in clot management in PM texts was introducing the target organ for some of the recommended herbs like Carum carvi and Bunium persicum for dissolving blood clot in stomach and Commiphora mukul for thrombosed hemorrhoid. It seems review of PM recommendations can help to design future researches for antithrombotic drugs discovering with more effectiveness and safety.
血栓形成是广泛的血管疾病中发病率和死亡率的主要原因之一。由于血栓栓塞性疾病的高发，人们正在研究新的抗血栓药物，这些药物的不良反应有限，其中草药被认为是替代疗法。波斯医学（PM）作为一种传统医学，基于其自身的原则和药物的开发，具有良好的药物治疗潜力，可以通过研究 PM 文献来实现。在 PM 手稿中，有一些概念表达了对血栓的管理和抗血栓特性。本研究根据现有知识，综述了 PM 文献中提到的药用植物在血栓管理方面的药理学作用。PM 中提到的用于管理血栓的植物属于 12 个科，其中伞形科、唇形科和菊科是最常见的科。在提出的植物中，大蒜、迷迭香、乳香、芝麻、甘菊和红花在现代抗血栓研究中得到了最多的研究，而对于一些植物，如 Helichrysum stoechas、Dracocephalum kotschi、Carum carvi、Bunium persicum 和 Lagoecia cuminoides，则没有发现相关证据。PM 文本中血栓管理的一个有趣之处是，为 Carum carvi 和 Bunium persicum 等推荐草药确定了作用部位，Carum carvi 和 Bunium persicum 可溶解胃部的血栓，Commiphora mukul 可治疗血栓性痔疮。看来，对 PM 建议的回顾可以帮助设计未来的抗血栓药物研究，以提高药物的有效性和安全性。
