Braun A R, Chase T N
Eur J Pharmacol. 1986 Nov 19;131(2-3):301-6. doi: 10.1016/0014-2999(86)90588-1.
Administered independently, the selective D-1 and D-2 agonists SKF 38393 and LY 171555 elicited dose dependent increases in complex motor behaviors such as locomotion or grooming. Typical stereotypic behaviors were observed only when these agents were combined and only at the higher doses of the D-1 agonist. AMPT pretreatment blocked the effects of the agonists administered independently, but all classes of behavior could be induced when they were administered in combination. Thus, expression of dopamine agonist induced behaviors requires concurrent activation of D-1 and D-2 receptors; the nature of the behavior appears to depend upon the ratio of D-1 to D-2 receptor activation.
单独给药时，选择性D-1和D-2激动剂SKF 38393和LY 171555可引起复杂运动行为（如运动或梳理毛发）的剂量依赖性增加。仅当这些药物联合使用且仅在较高剂量的D-1激动剂时才观察到典型的刻板行为。AMPT预处理可阻断单独给药的激动剂的作用，但当它们联合给药时可诱导所有类型的行为。因此，多巴胺激动剂诱导行为的表达需要D-1和D-2受体的同时激活；行为的性质似乎取决于D-1与D-2受体激活的比例。
