Tsukada T, Tejima T, Amano J, Suzuki A, Numano F
Department of Internal Medicine (3), Tokyo Medical and Dental University, Japan.
Exp Mol Pathol. 1988 Apr;48(2):193-205. doi: 10.1016/0014-4800(88)90056-1.
The authors have performed immunocytochemical surveys on atherosclerotic changes observed in saphenous vein aortocoronary bypass grafts, comparing the changes occurring in coronary and aortic lesions. The two monoclonal antibodies used in this study were obtained by T. Tsukada. One of them, named HHF35, exhibited specificity to smooth muscle cells; the other, named HAM56, was specific to macrophages. These immunocytochemical studies clearly demonstrated that cells encountered within the fibrous intimal thickening in the vein graft were inevitably smooth muscle cell in origin. Macrophages were seldom seen in the grafts examined. In contrast to vein grafts, macrophages were noted within the intima of all specimens from arterial atherosclerotic lesions obtained from the same patients. These studies suggest a difference in the progression of intimal thickening between the venous graft and the arterial atherosclerotic lesions.
作者对在大隐静脉主动脉冠状动脉旁路移植术中观察到的动脉粥样硬化变化进行了免疫细胞化学研究，比较了冠状动脉和主动脉病变中发生的变化。本研究中使用的两种单克隆抗体由冢田彻提供。其中一种名为HHF35，对平滑肌细胞具有特异性；另一种名为HAM56，对巨噬细胞具有特异性。这些免疫细胞化学研究清楚地表明，在静脉移植物纤维内膜增厚中遇到的细胞不可避免地起源于平滑肌细胞。在所检查的移植物中很少见到巨噬细胞。与静脉移植物相反，在从同一患者获得的动脉粥样硬化病变的所有标本内膜中均发现了巨噬细胞。这些研究表明静脉移植物和动脉粥样硬化病变在内膜增厚进展方面存在差异。
