Yaqoob Sundas Bahar, Adnan Rohana, Rameez Khan Raja Muhammad, Rashid Mohammad
Department of Zoology, Mirpur University of Science and Technology Mirpur, Mirpur, Pakistan.
School of Chemical Sciences, Universiti Sains Malaysia, Penang, Malaysia.
Front Chem. 2020 Jun 3;8:376. doi: 10.3389/fchem.2020.00376. eCollection 2020.
Herein, the role of metal-based nanoparticles (NPs) in biomedical analysis and the treatment of critical deceases been highlighted. In the world of nanotechnology, noble elements such as the gold/silver/palladium (Au/Ag/Pd) NPs are the most promising emerging trend to design bioengineering materials that could to be employed as modern diagnostic tools and devices to combat serious diseases. NPs are considered a powerful and advanced chemical tool to diagnose and to cure critical ailments such as HIV, cancer, and other types of infectious illnesses. The treatment of cancer is the most significant application of nanotechnology which is based on premature tumor detection and analysis of cancer cells through Nano-devices. The fascinating characteristic properties of NPs-such as high surface area, high surface Plasmon resonance, multi-functionalization, highly stable nature, and easy processing-make them more prolific for nanotechnology. In this review article, the multifunctional roles of Au/Ag/Pd NPs in the field of medical science, the physicochemical toxicity dependent properties, and the interaction mechanism is highlighted. Due to the cytotoxicity of Ag/Au/Pd NPs, the conclusion and future remarks emphasize the need for further research to minimize the toxicity of NPs in the bio-medicinal field.
在此,金属基纳米颗粒(NPs)在生物医学分析和重症疾病治疗中的作用得到了突出强调。在纳米技术领域,金/银/钯(Au/Ag/Pd)等贵金属元素的纳米颗粒是设计生物工程材料最具前景的新兴趋势,这些材料可作为现代诊断工具和设备来对抗严重疾病。纳米颗粒被认为是一种强大而先进的化学工具,可用于诊断和治疗诸如艾滋病毒、癌症及其他类型传染病等重症疾病。癌症治疗是纳米技术最重要的应用,它基于通过纳米设备对肿瘤的早期检测和癌细胞分析。纳米颗粒具有诸如高表面积、高表面等离子体共振、多功能化、高度稳定的性质以及易于加工等迷人特性,这使得它们在纳米技术中更具成效。在这篇综述文章中,突出强调了Au/Ag/Pd纳米颗粒在医学领域的多功能作用、物理化学毒性相关特性以及相互作用机制。由于Ag/Au/Pd纳米颗粒的细胞毒性,结论和未来展望强调需要进一步研究以将纳米颗粒在生物医学领域的毒性降至最低。