School of Mechanical Engineering, Beijing Institute of Technology, Beijing, China.
Department of IBT, Bharath Institute of Higher Education & Research, Bharath University, Chennai, Tamil Nadu, India.
J Biomol Struct Dyn. 2022 Jul;40(10):4766-4773. doi: 10.1080/07391102.2020.1858965. Epub 2020 Dec 10.
The utilization of photodynamic therapy (PDT) has been rapidly increasing due to its advantage as an effective treatment modality for cancer. The organic photosensitizers employed for PDT have some disadvantages, including high toxicity, non-selectivity toward tumors and poor absorption of light. The low light penetration into the tumor sites resulting from low wavelength of absorption and long-term skin photosensitivity. Hence, the attention toward non-toxic inorganic photosensitizers like noble metal nanoparticles (NPs) has been increasing nowadays. In bioscience, NPs are replacing organic dyes since they have photostability and non-toxicity. Generally, nanomaterials can easily form compounds with other substances as well as organic materials and the modified NPs surface enhances the chemical activity. Among the metal NPs, noble metals, especially gold and silver are attractive because of their size and shape-dependent unique optoelectronic properties. The coating of inorganic/organic materials on top of the noble metal makes the NPs bio-compatible and less toxic. Furthermore, Ag- and Au-based inorganic/organic complex NPs could offer a new possibility because of their unique structures. Meanwhile, the coating of inorganic/organic complex NPs protects the noble metals and stabilizes them against chemical corrosion and enhances the production of reactive oxygen species. Thus, in this review, we have highlighted the role of Ag- and Au-based inorganic/organic hybrid nano-photosensitizers in photodynamic therapy.Communicated by Ramaswamy H. Sarma.
由于光动力疗法 (PDT) 作为癌症有效治疗方法的优势，其应用正在迅速增加。用于 PDT 的有机光敏剂存在一些缺点，包括高毒性、对肿瘤的非选择性和光吸收不良。由于吸收波长低和长期皮肤光敏性，导致低光穿透到肿瘤部位。因此，目前人们越来越关注无毒的无机光敏剂，如贵金属纳米粒子 (NPs)。在生物科学中， NPs 正在取代有机染料，因为它们具有光稳定性和非毒性。通常，纳米材料很容易与其他物质以及有机材料形成化合物，并且修饰后的 NPs 表面增强了化学活性。在金属 NPs 中，贵金属，尤其是金和银因其尺寸和形状依赖性的独特光电特性而具有吸引力。在贵金属的顶部涂覆无机/有机材料可使 NPs 具有生物相容性和较低的毒性。此外，基于 Ag 和 Au 的无机/有机复合 NPs 由于其独特的结构，可能提供新的可能性。同时，无机/有机复合 NPs 的涂层可保护贵金属，防止其受到化学腐蚀，并增强活性氧物质的产生。因此，在本综述中，我们强调了基于 Ag 和 Au 的无机/有机杂化纳米光敏剂在光动力疗法中的作用。由 Ramaswamy H. Sarma 传达。
