Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, P.O. Box: 13145-784, Tehran, Iran.
Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2020 Nov;393(11):2081-2091. doi: 10.1007/s00210-020-01916-z. Epub 2020 Jun 24.
Sleep is involved in maintaining energy, regulating heat, and recovering tissues. Furthermore, proper cognitive functions need sufficient sleep. Many studies have revealed the impairment effect of sleep deprivation (SD) on cognitive functions including learning and memory. Alpha lipoic acid (ALA) is a potent free radical scavenger, biological antioxidant, and neuroprotective agent. Furthermore, ALA improves learning and memory performance, decreases oxidative stress, and enhances antioxidant biomarkers. In this study, we aimed to investigate the effect of ALA on social interaction and passive avoidance memories in sleep-deprived rats. Total sleep deprivation (TSD) apparatus was used to induce SD (for 24 h). Three-chamber paradigm test and shuttle box apparatus were used to evaluate social interaction and passive avoidance memory, respectively. Rats' locomotor apparatus was used to assess locomotion. ALA was administered intraperitoneally at doses of 17 and 35 mg/kg for 3 consecutive days. The results showed SD impaired both types of memories. ALA at the dose of 35 mg/kg restored social interaction memory in sleep-deprived rats; while, at the dose of 17 mg/kg attenuated impairment effect of SD. Moreover, ALA at the dose of 35 mg/kg impaired passive avoidance memory in sham-SD rats and at both doses did not rescue passive avoidance memory in sleep-deprived rats. In conclusion, ALA showed impairment effect on passive avoidance memory, while improved social interaction memory in sleep-deprived rats.
睡眠在维持能量、调节体温和恢复组织方面起着重要作用。此外，适当的认知功能需要充足的睡眠。许多研究表明，睡眠剥夺（SD）对学习和记忆等认知功能有损害作用。α-硫辛酸（ALA）是一种有效的自由基清除剂、生物抗氧化剂和神经保护剂。此外，ALA 可以改善学习和记忆表现，降低氧化应激，增强抗氧化生物标志物。在这项研究中，我们旨在研究 ALA 对睡眠剥夺大鼠社交互动和被动回避记忆的影响。总睡眠剥夺（TSD）装置用于诱导 SD（24 小时）。三箱测试和穿梭箱装置分别用于评估社交互动和被动回避记忆，大鼠的运动装置用于评估运动。ALA 连续 3 天腹腔注射给药，剂量为 17 和 35mg/kg。结果表明，SD 损害了这两种记忆。35mg/kg 的 ALA 恢复了睡眠剥夺大鼠的社交互动记忆；而 17mg/kg 的 ALA 则减轻了 SD 的损害作用。此外，35mg/kg 的 ALA 损害了假手术-SD 大鼠的被动回避记忆，而两种剂量均不能挽救睡眠剥夺大鼠的被动回避记忆。综上所述，ALA 对被动回避记忆有损害作用，而对睡眠剥夺大鼠的社交互动记忆有改善作用。
