Department of Biochemistry, Faculty of Medicine, Sakarya University, Korucuk Campus Adapazari, 54290, Sakarya, Turkey.
Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Ir J Med Sci. 2021 Feb;190(1):97-106. doi: 10.1007/s11845-020-02272-w. Epub 2020 Jun 24.
Hypertension (HT) is a disease associated with endothelial dysfunction which is related to some adipokines and pro- and anti-inflammatory cytokines.
Our aim was to investigate roles of apelin, omentin-1, and vaspin in essential HT and to evaluate their relationships with other pro- and anti-inflammatory cytokines, trace elements, and oxidative stress. We also investigated these parameters to determine asymptomatic target organ damage period and grading essential hypertension.
One hundred fifty-three patients diagnosed with essential hypertension and 45 healthy controls were included in the study. Hypertension was defined as a systolic blood pressure > 140 mmHg and/or a diastolic blood pressure > 90 mm Hg or current use of an antihypertensive medication. The patients who had secondary HT, other chronic metabolic, cardiovascular, cerebrovascular diseases were excluded. History and physical exam including detailed cardiovascular examination were performed in all participants. Adipokines, cytokines, trace elements, lipid peroxidation, and ischemia-modified albumin levels were measured in blood samples by biochemical methods.
Vaspin, IL-4, IL-8, IL-10, selenium, and zinc levels were significantly lower in the HT group compared to healthy controls while omentin-1, TNF-α, copper, iron, MDA, SOD, and IMA-C levels were significantly higher in HT patients compared to controls. Multiple ordinal regression revealed that TNF-α, IL-10, and body mass index of patients were statistically significant independent predictors (P = 0.024, P = 0.019, and P = 0.032, respectively) for grading of HT. IL-4 and IL-10 were significantly higher in patients with asymptomatic target organ damage, compared to patients without asymptomatic target organ damage (P = 0.032 and P = 0.015, respectively). Our findings suggest that adipokines apelin, omentin, and vaspin may be involved in hypertension by a complex interaction with the anti- and pro-inflammatory cytokines, trace elements, and oxidative stress pathways.
高血压（HT）是一种与内皮功能障碍相关的疾病，内皮功能障碍与一些脂肪因子和促炎及抗炎细胞因子有关。
我们旨在研究 Apelin、Omentin-1 和 Vaspin 在原发性高血压中的作用，并评估它们与其他促炎和抗炎细胞因子、微量元素和氧化应激的关系。我们还研究了这些参数，以确定无症状靶器官损伤期和原发性高血压分级。
将 153 例诊断为原发性高血压的患者和 45 例健康对照者纳入本研究。高血压的定义为收缩压>140mmHg 和/或舒张压>90mmHg 或正在使用降压药物。排除患有继发性高血压、其他慢性代谢性、心血管和脑血管疾病的患者。所有参与者均进行了病史和体格检查，包括详细的心血管检查。通过生化方法测量血液样本中的脂肪因子、细胞因子、微量元素、脂质过氧化和缺血修饰白蛋白水平。
与健康对照组相比，HT 组的 Vaspin、IL-4、IL-8、IL-10、硒和锌水平显著降低，而 Omentin-1、TNF-α、铜、铁、MDA、SOD 和 IMA-C 水平显著升高。多元有序回归显示，TNF-α、IL-10 和患者的体重指数是 HT 分级的统计学上显著的独立预测因子（P=0.024、P=0.019 和 P=0.032）。与无无症状靶器官损伤的患者相比，无症状靶器官损伤患者的 IL-4 和 IL-10 显著升高（P=0.032 和 P=0.015）。我们的研究结果表明，脂肪因子 Apelin、Omentin 和 Vaspin 可能通过与抗炎和促炎细胞因子、微量元素和氧化应激途径的复杂相互作用参与高血压的发生。
