肥胖个体中网膜素和内脂素与胰岛素抵抗的浓度比较。

Concentrations of omentin and vaspin versus insulin resistance in obese individuals.

机构信息

Division of Biology of Civilization-Related Diseases, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Biomed Pharmacother. 2016 Oct;83:542-547. doi: 10.1016/j.biopha.2016.07.012. Epub 2016 Jul 21.

DOI:10.1016/j.biopha.2016.07.012

PMID:27449535

Abstract

INTRODUCTION

Omentin and vaspin are adipokines manifesting a potentially protective action against obesity-associated metabolic disturbances.

AIM

Evaluation of relationship between serum concentrations of omentin and vaspin on one hand and indices of insulin resistance and anthropometric parameters in obese individuals on the other.

MATERIAL AND METHODS

The studies were conducted on 64 individuals. The investigated group (37 obese patients) included the subgroup with normal glucose tolerance (NGT) and with abnormal glucose tolerance (AGT). The control group (n=27) included healthy individuals with normal body weight. In all participants anthropometric analyses and biochemical tests, including estimation of omentin and vaspin concentrations were performed, and insulin resistance by HOMA-IR was evaluated.

RESULTS

Concentrations of examined adipokines manifested no significant differences between the examined groups. Median values of the index defining ratio between studied adipokine and degree of insulin resistance, i.e. omentin/HOMA-IR, proved to be different in the investigated and the control group while no such difference could be noted in cases of vaspin/HOMA-IR indices. In the studied population a negative relationship was detected between serum concentration of omentin and systolic blood pressure (p<0.04). Values of omentin/HOMA-IR index manifested a correlation with values of most anthropometric parameters (p<0.0001), blood pressure (p<0.0001) concentrations of TG (p<000.1) and HDL (p<0.0001), ISI (p<0.00001), ISI (p<0.0001), Quicki (p<0.00001) and fasting insulinaemia (p<0.00001). In the case of vaspin/HOMA-IR index only its positive relationship with HDL concentration was noted (p<0.05).

CONCLUSION

In context of date of correlation, multiple regression and values of area of under receiver operating characteristics curve omentin, as compared to vaspin, seems to provide a better predictor of insulin resistance in obese individuals.

摘要

简介

网膜素和内脂素是脂肪细胞因子，表现出对肥胖相关代谢紊乱的潜在保护作用。

目的

评估血清网膜素和内脂素浓度与肥胖个体胰岛素抵抗指数和人体测量参数之间的关系。

材料和方法

本研究共纳入 64 名参与者。研究组（37 名肥胖患者）包括糖耐量正常（NGT）和糖耐量异常（AGT）亚组。对照组（n=27）包括体重正常的健康个体。对所有参与者进行人体测量分析和生化检测，包括网膜素和内脂素浓度的评估，以及用 HOMA-IR 评估胰岛素抵抗。

结果

在检查的各组之间，检查的脂肪细胞因子浓度没有显著差异。研究中定义的两种脂肪细胞因子与胰岛素抵抗程度之比的指数，即网膜素/HOMA-IR，在研究组和对照组之间存在差异，而内脂素/HOMA-IR 指数则没有差异。在研究人群中，血清网膜素浓度与收缩压呈负相关（p<0.04）。网膜素/HOMA-IR 指数的值与大多数人体测量参数（p<0.0001）、血压（p<0.0001）、TG（p<000.1）和 HDL（p<0.0001）浓度、ISI（p<0.00001）、Quicki（p<0.00001）和空腹胰岛素血症（p<0.00001）呈正相关。而内脂素/HOMA-IR 指数仅与 HDL 浓度呈正相关（p<0.05）。