Buyukinan Muammer, Atar Muge, Can Ummugulsum, Pirgon Ozgur, Guzelant Asuman, Deniz Isa
1 Department of Pediatric Endocrinology, Konya Training and Research Hospital , Konya, Turkey .
2 Department of Pediatric Endocrinology and Diabetes, Faculty of Medicine, Suleyman Demirel University , Isparta, Turkey .
Metab Syndr Relat Disord. 2018 Mar;16(2):76-81. doi: 10.1089/met.2017.0133. Epub 2018 Jan 10.
Excess visceral fat accumulation results in altered release of adipokines. The aim of this study was to examine the relationship between new adipokines (omentin-1 and vaspin), insulin resistance, and serum inflammatory markers in obese subjects with metabolic syndrome (MS).
The study included a total of 121 obese children (79 females and 42 males, aged 12-17 years old). The obese subjects were divided into two groups based on the presence or absence of MS criteria (MS group and non-MS group). Serum omentin-1, vaspin, and high-sensitivity C-reactive protein (CRP) were measured in addition to the other glucose metabolism parameters.
MS was diagnosed in 45 obese children and 76 children did not meet the MS criteria. Serum omentin-1 (289.5 ± 51.9 ng/mL vs. 268.2 ± 60 ng/mL, P = 0.03) levels were significantly lower in the MS group compared to the non-MS group. Serum vaspin levels (1058.3 ± 118 pg/mL vs. 1178.6 ± 158 pg/mL, P = 0.02) were higher in the MS group than the non-MS group. CRP levels correlated well with both the adipokines (r = -0.236, P = 0.04 for omentin-1 and r = 0.296, P = 0.008 for vaspin), although these adipokines did not show statistically significant correlations with fasting glucose-insulin levels, homeostasis model assessment of insulin resistance, and 2 hr postload glucose level.
Higher vaspin and lower omentin-1 levels were determined in obese MS children compared to non-MS children and these adipokines were significantly correlated with high CRP values. These data support the view that adipokines in MS children contribute to increased inflammation markers before abnormal glucose metabolism.
内脏脂肪过度堆积会导致脂肪因子释放改变。本研究旨在探讨新脂肪因子（网膜素-1和内脏脂肪素）、胰岛素抵抗与代谢综合征（MS）肥胖受试者血清炎症标志物之间的关系。
本研究共纳入121名肥胖儿童（79名女性，42名男性，年龄12 - 17岁）。根据是否符合MS标准，将肥胖受试者分为两组（MS组和非MS组）。除其他葡萄糖代谢参数外，还检测了血清网膜素-1、内脏脂肪素和高敏C反应蛋白（CRP）。
45名肥胖儿童被诊断为MS，76名儿童不符合MS标准。与非MS组相比，MS组血清网膜素-1水平（289.5±51.9 ng/mL对268.2±60 ng/mL，P = 0.03）显著降低。MS组血清内脏脂肪素水平（1058.3±118 pg/mL对1178.6±158 pg/mL，P = 0.02）高于非MS组。CRP水平与这两种脂肪因子均显著相关（网膜素-1的r = -0.236，P = 0.04；内脏脂肪素的r = 0.296，P = 0.008），尽管这些脂肪因子与空腹血糖-胰岛素水平、胰岛素抵抗稳态模型评估及餐后2小时血糖水平无统计学显著相关性。
与非MS肥胖儿童相比，MS肥胖儿童的内脏脂肪素水平较高，网膜素-1水平较低，且这些脂肪因子与高CRP值显著相关。这些数据支持以下观点：MS儿童体内的脂肪因子在葡萄糖代谢异常之前就导致炎症标志物增加。
