• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长链非编码 RNA FAM83H-AS1 通过 miR-10a-5p/Girdin 轴促进食管鳞状细胞癌进展。

LncRNA FAM83H-AS1 promotes oesophageal squamous cell carcinoma progression via miR-10a-5p/Girdin axis.

机构信息

Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

出版信息

J Cell Mol Med. 2020 Aug;24(16):8962-8976. doi: 10.1111/jcmm.15530. Epub 2020 Jun 24.

DOI:10.1111/jcmm.15530
PMID:32583631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7417701/
Abstract

Long non-coding RNAs (lncRNAs) have been well demonstrated to emerge as crucial regulators in cancer progression, and they can function as regulatory network based on their interactions. Although the biological functions of FAM83H-AS1 have been confirmed in various tumour progressions, the underlying molecular mechanisms of FAM83H-AS1 in oesophageal squamous cell carcinoma (ESCC) remained poorly understood. To address this, we treated human oesophageal cancer cell line Eca109 cells with TGF-β and found FAM83H-AS1 was notably overexpressed. In the present study, FAM83H-AS1 was observed to be significantly up-regulated in ESCC tissues and was associated with TNM stage, pathological differentiation and lymph node metastasis. FAM83H-AS1 reinforced oesophageal cancer cell proliferation, migration and invasion, and participated in epithelial-to-mesenchymal transition (EMT) process at mRNA and protein levels. In addition, a concordant regulation between FAM83H-AS1 and its sense strand FAM83H was detected at the transcriptional and translational levels. Furthermore, FAM83H-AS1 could act as competing endogenous RNA to affect the expression of Girdin by sponging miR-10a-5p verified by RIP and luciferase reporter assays. Consequently, the study provided a unique perspective of FAM83H-AS1 in ESCC progression, which may be considered as potential biomarker and therapeutic target for ESCC therapy.

摘要

长链非编码 RNA（lncRNA）已被充分证明是癌症进展中的关键调节因子，它们可以基于相互作用发挥调节网络的功能。虽然 FAM83H-AS1 的生物学功能已在各种肿瘤进展中得到证实，但 FAM83H-AS1 在食管鳞状细胞癌（ESCC）中的潜在分子机制仍知之甚少。为了解决这个问题，我们用 TGF-β处理人食管癌细胞系 Eca109 细胞，发现 FAM83H-AS1 明显过表达。在本研究中，我们观察到 FAM83H-AS1 在 ESCC 组织中显著上调，并与 TNM 分期、病理分化和淋巴结转移相关。FAM83H-AS1 增强了食管癌细胞的增殖、迁移和侵袭，并在 mRNA 和蛋白水平上参与了上皮间质转化（EMT）过程。此外，在转录和翻译水平上检测到 FAM83H-AS1 与其有义链 FAM83H 之间的一致调节。此外，FAM83H-AS1 可以作为竞争内源性 RNA 通过海绵 miR-10a-5p 来影响 Girdin 的表达，这一点通过 RIP 和荧光素酶报告基因实验得到了验证。因此，该研究为 FAM83H-AS1 在 ESCC 进展中的作用提供了一个独特的视角，它可能被认为是 ESCC 治疗的潜在生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/858e53d84870/JCMM-24-8962-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/7eee43ba06fa/JCMM-24-8962-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/0b29660d3310/JCMM-24-8962-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/014847947416/JCMM-24-8962-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/6f1f7fd43e02/JCMM-24-8962-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/c05874020686/JCMM-24-8962-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/858e53d84870/JCMM-24-8962-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/7eee43ba06fa/JCMM-24-8962-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/0b29660d3310/JCMM-24-8962-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/014847947416/JCMM-24-8962-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/6f1f7fd43e02/JCMM-24-8962-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/c05874020686/JCMM-24-8962-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/918b/7417701/858e53d84870/JCMM-24-8962-g007.jpg

相似文献

1
LncRNA FAM83H-AS1 promotes oesophageal squamous cell carcinoma progression via miR-10a-5p/Girdin axis.长链非编码 RNA FAM83H-AS1 通过 miR-10a-5p/Girdin 轴促进食管鳞状细胞癌进展。
J Cell Mol Med. 2020 Aug;24(16):8962-8976. doi: 10.1111/jcmm.15530. Epub 2020 Jun 24.
2
LncRNA MNX1-AS1 promotes progression of esophageal squamous cell carcinoma by regulating miR-34a/SIRT1 axis.长链非编码 RNA MNX1-AS1 通过调节 miR-34a/SIRT1 轴促进食管鳞状细胞癌的进展。
Biomed Pharmacother. 2019 Aug;116:109029. doi: 10.1016/j.biopha.2019.109029. Epub 2019 Jun 3.
3
LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway.长链非编码 RNA DDX11 反义 RNA 1 通过海绵吸附 miR-30d-5p 来调节 SNAI1/ZEB2 表达和 Wnt/β-catenin 通路，促进食管鳞癌细胞的 EMT 过程。
Bioengineered. 2021 Dec;12(2):11425-11440. doi: 10.1080/21655979.2021.2008759.
4
LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis.长链非编码 RNA FAM83H-AS1 通过调控 miR-136-5p/metadherin 轴促进三阴性乳腺癌的进展。
Aging (Albany NY). 2020 Feb 17;12(4):3594-3616. doi: 10.18632/aging.102832.
5
Regulation of IncRNA ZNF667-AS1 in Proliferation and Invasion of Esophageal Squamous Cell Carcinoma Cells via Mediating ceRNA Network.长链非编码 RNA ZNF667-AS1 通过调控 ceRNA 网络对食管鳞癌细胞增殖和侵袭的影响
Crit Rev Eukaryot Gene Expr. 2022;32(6):57-68. doi: 10.1615/CritRevEukaryotGeneExpr.2022042267.
6
Non-coding RNA MFI2-AS1 promotes colorectal cancer cell proliferation, migration and invasion through miR-574-5p/MYCBP axis.非编码 RNA MFI2-AS1 通过 miR-574-5p/MYCBP 轴促进结直肠癌细胞增殖、迁移和侵袭。
Cell Prolif. 2019 Jul;52(4):e12632. doi: 10.1111/cpr.12632. Epub 2019 May 16.
7
FAM83H-AS1/miR-485-5p/MEF2D axis facilitates proliferation, migration and invasion of hepatocellular carcinoma cells.FAM83H-AS1/miR-485-5p/MEF2D 轴促进肝癌细胞的增殖、迁移和侵袭。
BMC Cancer. 2021 Dec 7;21(1):1310. doi: 10.1186/s12885-021-08923-0.
8
LncRNA ZEB1-AS1 down-regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma.LncRNA ZEB1-AS1 下调通过抑制食管鳞癌细胞中 ZEB1 的表达抑制增殖和侵袭。
J Cell Mol Med. 2019 Dec;23(12):8206-8218. doi: 10.1111/jcmm.14692. Epub 2019 Oct 22.
9
TMEM161B-AS1 suppresses proliferation, invasion and glycolysis by targeting miR-23a-3p/HIF1AN signal axis in oesophageal squamous cell carcinoma.TMEM161B-AS1 通过靶向 miR-23a-3p/HIF1AN 信号轴抑制食管鳞癌细胞的增殖、侵袭和糖酵解。
J Cell Mol Med. 2021 Jul;25(14):6535-6549. doi: 10.1111/jcmm.16652. Epub 2021 May 27.
10
A novel long noncoding RNA, LOC440173, promotes the progression of esophageal squamous cell carcinoma by modulating the miR-30d-5p/HDAC9 axis and the epithelial-mesenchymal transition.一种新型长链非编码RNA，即LOC440173，通过调节miR-30d-5p/HDAC9轴和上皮-间质转化来促进食管鳞状细胞癌的进展。
Mol Carcinog. 2020 Dec;59(12):1392-1408. doi: 10.1002/mc.23264. Epub 2020 Oct 20.

引用本文的文献

1
The emerging roles and mechanisms of FAM83H‑AS1 in cancer: Pathophysiology and therapeutic implications (Review).FAM83H-AS1在癌症中的新兴作用和机制：病理生理学及治疗意义（综述）
Oncol Lett. 2025 Apr 7;29(6):270. doi: 10.3892/ol.2025.15016. eCollection 2025 Jun.
2
Molecular Dynamics of Breast Cancer Subtypes: The Role of FAM83H-AS1 Long Non-coding RNA in Breast Cancer Metastasis.乳腺癌亚型的分子动力学：FAM83H-AS1长链非编码RNA在乳腺癌转移中的作用
Breast Cancer Res Treat. 2025 Apr;210(3):645-659. doi: 10.1007/s10549-024-07603-4. Epub 2025 Feb 1.
3
Comprehensive analysis of bioinformatics and system biology reveals the association between Girdin and hepatocellular carcinoma.

本文引用的文献

1
Family with Sequence Similarity 83 Member H Promotes the Viability and Metastasis of Cervical Cancer Cells and Indicates a Poor Prognosis.家族性序列相似性 83 成员 H 促进宫颈癌细胞的存活和转移，并预示着不良预后。
Yonsei Med J. 2019 Jul;60(7):611-618. doi: 10.3349/ymj.2019.60.7.611.
2
FAM83H is involved in stabilization of β-catenin and progression of osteosarcomas.FAM83H 参与稳定β-连环蛋白和骨肉瘤的进展。
J Exp Clin Cancer Res. 2019 Jun 18;38(1):267. doi: 10.1186/s13046-019-1274-0.
3
ELK1-induced upregulation of lncRNA TRPM2-AS promotes tumor progression in gastric cancer by regulating miR-195/ HMGA1 axis.
生物信息学和系统生物学的综合分析揭示了Girdin与肝细胞癌之间的关联。
PLoS One. 2024 Dec 13;19(12):e0315534. doi: 10.1371/journal.pone.0315534. eCollection 2024.
4
Roles of long non‑coding RNAs in esophageal cell squamous carcinoma (Review).长链非编码 RNA 在食管鳞癌中的作用（综述）。
Int J Mol Med. 2024 Aug;54(2). doi: 10.3892/ijmm.2024.5396. Epub 2024 Jul 4.
5
The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers.转化生长因子-β 信号通路在胃肠道癌症中的作用。
Biomolecules. 2023 Oct 19;13(10):1551. doi: 10.3390/biom13101551.
6
LncRNA NR_003508 Suppresses -Induced Programmed Necrosis via Sponging miR-346-3p to Regulate RIPK1.长链非编码 RNA NR_003508 通过海绵吸附 miR-346-3p 抑制 - 诱导的程序性细胞坏死，从而调节 RIPK1。
Int J Mol Sci. 2023 Apr 28;24(9):8016. doi: 10.3390/ijms24098016.
7
Advances in targeting of miR‑10‑associated lncRNAs/circRNAs for the management of cancer (Review).靶向miR-10相关lncRNA/circRNA用于癌症治疗的研究进展（综述）
Oncol Lett. 2023 Jan 19;25(3):89. doi: 10.3892/ol.2023.13675. eCollection 2023 Mar.
8
Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma.新型长非编码 RNA LINC02820 增强 TNF 信号通路重塑细胞骨架并增强食管鳞状细胞癌的转移。
Cancer Gene Ther. 2023 Feb;30(2):375-387. doi: 10.1038/s41417-022-00554-2. Epub 2022 Nov 10.
9
LncRNA FAM83H-AS1 promotes the malignant progression of pancreatic ductal adenocarcinoma by stabilizing FAM83H mRNA to protect β-catenin from degradation.长链非编码 RNA FAM83H-AS1 通过稳定 FAM83H mRNA 来保护 β-连环蛋白免于降解，从而促进胰腺导管腺癌的恶性进展。
J Exp Clin Cancer Res. 2022 Sep 29;41(1):288. doi: 10.1186/s13046-022-02491-2.
10
Integrative analysis of expression profile indicates the ECM receptor and LTP dysfunction in the glioma-related epilepsy.整合表达谱分析表明 ECM 受体和 LTP 功能障碍与胶质瘤相关癫痫有关。
BMC Genomics. 2022 Jun 8;23(1):430. doi: 10.1186/s12864-022-08665-8.
ELK1诱导的lncRNA TRPM2-AS上调通过调节miR-195/HMGA1轴促进胃癌肿瘤进展。
J Cell Biochem. 2019 Oct;120(10):16921-16933. doi: 10.1002/jcb.28951. Epub 2019 May 19.
4
Cellular functions of long noncoding RNAs.长非编码 RNA 的细胞功能。
Nat Cell Biol. 2019 May;21(5):542-551. doi: 10.1038/s41556-019-0311-8. Epub 2019 May 2.
5
Long non-coding RNA FAM83H-AS1 is regulated by human papillomavirus 16 E6 independently of p53 in cervical cancer cells.长链非编码 RNA FAM83H-AS1 受人类乳头瘤病毒 16 E6 调控，而与宫颈癌细胞中的 p53 无关。
Sci Rep. 2019 Mar 6;9(1):3662. doi: 10.1038/s41598-019-40094-8.
6
Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling.核长链非编码 RNA HOXD-AS1 通过抑制 HOXD3 诱导的整合素 β3 转录激活和 MAPK/AKT 信号通路抑制结直肠癌的生长和转移。
Mol Cancer. 2019 Mar 1;18(1):31. doi: 10.1186/s12943-019-0955-9.
7
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
8
LINC01133 as ceRNA inhibits gastric cancer progression by sponging miR-106a-3p to regulate APC expression and the Wnt/β-catenin pathway.LINC01133 通过海绵吸附 miR-106a-3p 来抑制胃癌进展，从而调节 APC 表达和 Wnt/β-catenin 通路。
Mol Cancer. 2018 Aug 22;17(1):126. doi: 10.1186/s12943-018-0874-1.
9
RETRACTED: Long noncoding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b/MMP9 axis.撤回：长链非编码 RNA HOXD-AS1 通过调控 miR-133b/MMP9 轴促进非小细胞肺癌迁移和侵袭。
Biomed Pharmacother. 2018 Oct;106:156-162. doi: 10.1016/j.biopha.2018.06.073. Epub 2018 Jun 27.
10
The TGFβ-induced lncRNA TBILA promotes non-small cell lung cancer progression in vitro and in vivo via cis-regulating HGAL and activating S100A7/JAB1 signaling.TGFβ 诱导的长链非编码 RNA TBILA 通过顺式调控 HGAL 和激活 S100A7/JAB1 信号促进非小细胞肺癌的体外和体内进展。
Cancer Lett. 2018 Sep 28;432:156-168. doi: 10.1016/j.canlet.2018.06.013. Epub 2018 Jun 15.