Department of Food Science and Human Nutrition, Faculty of Biosciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Eurofins Group, Sydney, Australia.
Cell Mol Biol (Noisy-le-grand). 2020 Jun 25;66(4):178-183.
Whole-blood choline, plasma choline and serum choline are emerging biomarkers in cardiovascular diseases (CVD). To examine the association of Whole-blood choline is an early predictor for cardiac events. In case control study, we enrolled 240 individuals including 120 normal (39 females and 82 males) and 120 cases (49 females and 71 males) where age limit was >40 years) Information through interviews, family disease history, 24 recall diet assessment and blood sampling. Odds ratios express the associated risks with CVD and without CVD patients. In healthy populations, good dietary habits and active lifestyle were observed. The number of participants with CVD were smokers than normal. In men, and women the risk was observed highly significant. (p=0.0049) Different blood parameters like Triglycerides, Uric Acid, Urea, Creatinine, CRP and ESR were non-significant observed. In females the low carbohydrates and high protein and frequent salad vegetable consumption observed. On the other hand, men consume more carbohydrates. Body mass index was significantly with p= 0.036 (OD 1.12 95% 1.00-1.26). The total fats (p=0.017) (OD 1.3301 95% 1.05-1.69) total carbohydrate (p=0.076) (OD 1.1536 95% 0.98-1.35) and total proteins (p=0.287) (OD 1.1456 95% 0.89-1.47) effecting respectively. The Blood choline level was significant observed between cases (p=0.026) OD (0.944 95%0.89- 0.99).
全血胆碱、血浆胆碱和血清胆碱是心血管疾病 (CVD) 的新兴生物标志物。研究表明，全血胆碱是心脏事件的早期预测指标。在病例对照研究中，我们招募了 240 名个体，包括 120 名正常（39 名女性和 82 名男性）和 120 名病例（49 名女性和 71 名男性），年龄限制大于 40 岁。通过访谈、家族病史、24 小时饮食回忆评估和采血获取信息。比值比表示与 CVD 和无 CVD 患者相关的风险。在健康人群中，观察到良好的饮食习惯和积极的生活方式。患有 CVD 的参与者的吸烟人数多于正常人群。在男性和女性中，风险观察到高度显著（p=0.0049）。观察到不同的血液参数，如甘油三酯、尿酸、尿素、肌酐、CRP 和 ESR 无显著差异。在女性中，观察到低碳水化合物和高蛋白质以及经常食用沙拉蔬菜。另一方面，男性摄入更多的碳水化合物。体重指数与 p=0.036（OD 1.12 95%1.00-1.26）显著相关。总脂肪（p=0.017）（OD 1.3301 95%1.05-1.69）、总碳水化合物（p=0.076）（OD 1.1536 95%0.98-1.35）和总蛋白质（p=0.287）（OD 1.1456 95%0.89-1.47）分别具有影响。病例组和对照组之间的血液胆碱水平差异显著（p=0.026），OD（0.944 95%0.89-0.99）。
