Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, 69100 Villeurbanne, France.
Department of Physiology, King Edward Medical University, Lahore 54000, Pakistan.
Molecules. 2022 Dec 26;28(1):210. doi: 10.3390/molecules28010210.
Neurotransmitters (NTs) are biologically active chemicals, which mediate the electrochemical transmission between neurons. NTs control numerous organic functions particularly crucial for life, including movement, emotional responses, and the physical ability to feel pleasure and pain. These molecules are synthesized from simple, very common precursors. Many types of NTs have both excitatory and inhibitory effects. Neurotransmitters' imbalance can cause many diseases and disorders, such as Parkinson's disease, depression, insomnia, increased anxiety, memory loss, etc. Natural food sources containing NTs and/or their precursors would be a potential option to help maintain the balance of NTs to prevent brain and psychiatric disorders. The level of NTs could be influenced, therefore, by targeting dietary habits and nutritional regimens. The progressive implementation of nutritional approaches in clinical practice has made it necessary to infer more about some of the nutritional NTs in neuropsychiatry. However, the importance of the intake of nutritional NTs requires further understanding, since there are no prior significant studies about their bioavailability, clinical significance, and effects on nerve cells. Interventional strategies supported by evidence should be encouraged.
神经递质（NTs）是生物活性化学物质，介导神经元之间的电化学传递。NTs 控制着许多对生命至关重要的有机功能，包括运动、情绪反应以及感受快乐和痛苦的身体能力。这些分子是由简单、非常常见的前体合成的。许多类型的 NTs 既有兴奋作用，也有抑制作用。NTs 的失衡会导致许多疾病和障碍，如帕金森病、抑郁症、失眠、焦虑增加、记忆力减退等。含有 NTs 和/或其前体的天然食物来源将是一种潜在的选择，可以帮助维持 NTs 的平衡，预防大脑和精神疾病。因此，可以通过针对饮食习惯和营养方案来影响 NTs 的水平。营养方法在临床实践中的逐步实施，使得我们必须更多地了解神经精神病学中的一些营养 NTs。然而，由于关于其生物利用度、临床意义以及对神经细胞的影响的先前研究并不显著，因此需要进一步了解摄入营养 NTs 的重要性。应该鼓励支持证据的干预策略。
