Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico.
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.
Cell Mol Biol (Noisy-le-grand). 2020 Jun 25;66(4):191-198.
Human skin possesses an essential function in the maintenance of individuals' health. However, it may undergo a variety of lesions that produce wounds of distinct severity. In this respect, instantly after any skin wound, the process of tissue regeneration and repair initiates. Nevertheless, diverse factors can delay this process, including bacterial infections, nutritional status, age, hypoxia, chronic diseases, necrosis, and vascular and arterial diseases. Thus, wound dressings are frequently used to improve wound healing. Those wound dressings are fabricated with diverse materials, which confer them different properties. In this regard, hyaluronic acid is a natural polysaccharide widely distributed in extracellular matrices of mammal tissues, which possesses remarkable attributes in terms of biocompatibility, biodegradability, and low cost. Moreover, hyaluronic acid exhibits several beneficial effects on wound healing, such as the decrease of inflammatory processes, regulation of tissue remodeling, and enhancement of angiogenesis. Therefore, in recent years, there is growing attention in this polysaccharide for the design and manufacture of novel wound dressings, which have shown encouraging properties. Here, we describe the different approaches of hyaluronic acid for the production of wound dressings, encompassing hydrogels, films, scaffolds, foams, topical formulations, and nanoformulations, as well as its beneficial effects on wound healing. Finally, we discuss perspectives about the use of hyaluronic acid in wound dressings.
人类皮肤在维持个体健康方面具有重要功能。然而,它可能会经历各种损伤,产生不同严重程度的伤口。在这方面,任何皮肤伤口发生后,组织再生和修复的过程都会立即启动。然而,许多因素会延迟这个过程,包括细菌感染、营养状况、年龄、缺氧、慢性疾病、坏死以及血管和动脉疾病。因此,经常使用伤口敷料来促进伤口愈合。这些伤口敷料是用不同的材料制成的,这些材料赋予了它们不同的特性。在这方面,透明质酸是一种天然多糖,广泛分布在哺乳动物组织的细胞外基质中,具有良好的生物相容性、可生物降解性和低成本等特性。此外,透明质酸对伤口愈合有多种有益的影响,如减少炎症过程、调节组织重塑和促进血管生成。因此,近年来,人们越来越关注这种多糖在新型伤口敷料设计和制造中的应用,这些敷料已经表现出了令人鼓舞的特性。在这里,我们描述了透明质酸用于生产伤口敷料的不同方法,包括水凝胶、薄膜、支架、泡沫、局部制剂和纳米制剂,以及它对伤口愈合的有益影响。最后,我们讨论了透明质酸在伤口敷料中的应用前景。
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