University of Campinas, Faculty of Chemical Engineering, Department of Materials Engineering and Bioprocess, Cidade Universitária Zeferino Vaz, Campinas, SP, Brazil.
University of Central Florida, NanoScience Technology Center, Orlando, FL, United States of America; Federal University of Alfenas, Institute of Science and Technology, Poços de Caldas, MG, Brazil.
Int J Biol Macromol. 2021 Mar 15;173:251-266. doi: 10.1016/j.ijbiomac.2021.01.100. Epub 2021 Jan 18.
Hyaluronic acid (HA) has already been consolidated in the literature as an extremely efficient biopolymer for biomedical applications. In addition to its biodegradability, HA also has excellent biological properties. In the nanofiber form, this polymer can mimic biological tissues, mainly the layers of the skin, and therefore has great potential as structures for the construction of wound dressings. Despite the numerous efforts from the scientific community proposing new dressings, this is an area in constant evolution. A dressing that brings together all the properties of an ideal dressing has not been developed yet. Electrospinning is a simple and versatile technique that correctly aligned with the functional properties of HA can produce multifunctional nanofiber structures capable of promoting skin recover quickly. This review discusses (i) key strategies for successful electrospinning of HA, (ii) main challenges and advances found in the electrospinning process, (iii) the bioactive properties of this polymer in the treatment of wounds, as well as (iv) the results obtained in the last decade by the in vitro and in vivo evaluation of the healing properties of these nanosystems.
透明质酸（HA）作为一种在生物医学应用中非常有效的生物聚合物，已经在文献中得到了巩固。除了可生物降解性，HA 还具有极好的生物特性。在纳米纤维形式下，这种聚合物可以模拟生物组织，主要是皮肤的各个层，因此作为伤口敷料的结构具有很大的潜力。尽管科学界做出了许多努力，提出了新的敷料，但这是一个不断发展的领域。一种具有理想敷料所有特性的敷料尚未开发出来。静电纺丝是一种简单而通用的技术，如果与 HA 的功能特性正确结合，可以生产出多功能的纳米纤维结构，能够促进皮肤快速恢复。本文综述了（i）成功静电纺丝 HA 的关键策略，（ii）静电纺丝过程中发现的主要挑战和进展，（iii）这种聚合物在治疗伤口方面的生物活性特性，以及（iv）过去十年中通过这些纳米系统的体外和体内评估获得的愈合特性结果。
