通过酶触发的聚合物解拉链将聚合物纳米粒子拆开：聚电解质复合物与两亲性纳米组装体。
Disassembly of polymeric nanoparticles with enzyme-triggered polymer unzipping: polyelectrolyte complexes vs. amphiphilic nanoassemblies.
机构信息
Department of Chemistry, University of Massachusetts, Amherst, MA-01003, USA.
出版信息
Chem Commun (Camb). 2020 Jul 28;56(60):8456-8459. doi: 10.1039/d0cc03257c.
Abstract
Alkaline phosphatase (ALP) responsive polymers, which can unzip from head to tail are reported. Hydrophilic and hydrophobic modification of the polymer was carried out for the formation of a polyelectrolyte complex and an amphiphilic nanoassembly, respectively, which offered distinct enzyme-triggered disassembly kinetics.
摘要
报道了一种可从头至尾解拉链的碱性磷酸酶（ALP）响应性聚合物。分别对聚合物进行亲水和疏水改性，以形成聚电解质复合物和两亲性纳米组装体，从而提供了明显的酶触发的解组装动力学。
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