Ding Yan, Kang Yuetong, Zhang Xi
Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Chem Commun (Camb). 2015 Jan 21;51(6):996-1003. doi: 10.1039/c4cc05878j.
Enzyme-responsive polymer assemblies have proved to be promising candidates for biomaterials, biomedicine and biosensing. Traditionally, these assemblies are prepared by the self-assembly of polymer building blocks which are covalently conjugated with enzyme-responsive moieties. Moreover, a supramolecular strategy has recently been developed for the preparation of enzyme-responsive polymer assemblies where the enzyme-responsive moieties are non-covalently complexed with the polymer building blocks. In addition, kinetic studies have been conducted on the enzyme-responsive behaviour of the polymer assemblies, which paves the way for tuning the response rate of the assemblies in a controlled manner.
酶响应性聚合物组装体已被证明是生物材料、生物医学和生物传感领域很有前景的候选物。传统上，这些组装体是通过与酶响应性部分共价共轭的聚合物构建块的自组装来制备的。此外，最近还开发了一种超分子策略来制备酶响应性聚合物组装体，其中酶响应性部分与聚合物构建块非共价复合。此外，还对聚合物组装体的酶响应行为进行了动力学研究，这为以可控方式调节组装体的响应速率铺平了道路。
