主体-客体相互作用介导的聚合组装体：用于药物和基因传递的多功能纳米颗粒。
Host-guest interaction mediated polymeric assemblies: multifunctional nanoparticles for drug and gene delivery.
机构信息
Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
ACS Nano. 2010 Feb 23;4(2):1049-59. doi: 10.1021/nn901213a.
Abstract
Novel core-shell structured nanoassemblies are assembled by a beta-cyclodextrin containing a positively charged host polymer and a hydrophobic guest polymer. The hydrophobic core of these types of assemblies serves as a nanocontainer to load and release the hydrophobic drugs, while the positively charged hydrophilic shell is able to condense the plasmid DNA and achieve its transfection/expression in osteoblast cells. These assemblies may be used as a new generation of multifunctional nanocarriers for simultaneous drug delivery and gene therapy.
摘要
新型核壳结构纳米组装体由含有带正电荷的主链聚合物和疏水性客链聚合物的β-环糊精组装而成。这类组装体的疏水性核作为纳米容器来装载和释放疏水性药物，而带正电荷的亲水性壳则能够使质粒 DNA 凝聚，并使其在成骨细胞中进行转染/表达。这些组装体可用作新一代多功能纳米载体，实现药物共递送和基因治疗。
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