College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, China.
Macromol Biosci. 2020 Aug;20(8):e2000153. doi: 10.1002/mabi.202000153. Epub 2020 Jun 25.
Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion method, amides and heparin-like polymer are introduced to functionalize the core-shell beads. The beads are successfully prepared with obvious core-shell structure, adequate thermostability and porous shell. Clotting times and protein adsorption are investigated to inspect the hemocompatibility property of the beads. The adsorption of bilirubin is systematically investigated by evaluating the effects of contacting time, initial concentration and temperature on the adsorption, which exhibits improved bilirubin adsorption amount for the beads with amides contained cores or/and shells. It is worth believing that the amides and heparin-like polymer co-functionalized core-shell beads may be utilized in the field of hemoperfusion for bilirubin adsorption.
肝功能障碍或代谢阻塞患者体内的胆红素过多可能导致黄疸并造成不可逆转的脑损伤，因此人们频繁研究新型胆红素吸附剂。在此，我们通过相转化法制备了基于氧化石墨烯的核@聚醚砜壳珠，并将酰胺基和肝素类似物聚合物引入到核壳珠中以对其进行功能化。成功制备了具有明显核壳结构、充足热稳定性和多孔壳的珠粒。通过考察凝血时间和蛋白质吸附，研究了珠粒的血液相容性。通过评估接触时间、初始浓度和温度对吸附的影响，系统地研究了胆红素的吸附，结果表明含有酰胺基的核或/和壳的珠粒具有更高的胆红素吸附量。可以相信，酰胺基和肝素类似物共功能化的核壳珠粒可能在胆红素吸附的血液灌流领域得到应用。
