Wahlin Y B, Matsson L
Department of Pedodontics, University of Umeå, Sweden.
Scand J Dent Res. 1988 Apr;96(2):128-36. doi: 10.1111/j.1600-0722.1988.tb01419.x.
This study reports the presence of oral mucosal lesions in 26 patients with acute leukemia during the initial weeks of treatment (induction period). For comparison, three groups of patients without malignant disorders (acute disorders, long-term hospitalization, antibiotic treatment) were included. All patients were treated at the University Hospital of Umeå, Sweden. During the period of hospitalization hemorrhages were seen in 14 of the 26 patients with leukemia. No specific location was found. A correlation between presence of hemorrhages and low platelet counts was noted. Eighteen of the patients revealed ulcerations during the period. Ulcerations were predominantly found on the buccal mucosa, the lips, and the tongue. A tendency to an increase in the number and severity of ulcers was noted during the period of induction therapy. A correlation between presence of ulcers and low granulocyte counts was found. Candidiasis-like changes were seen in eight of the patients with leukemia. Compared with the patients with leukemia the patients in the reference groups showed a low prevalence of oral mucosal lesions.
本研究报告了26例急性白血病患者在治疗初期（诱导期）出现口腔黏膜病变的情况。作为对照，纳入了三组无恶性疾病的患者（急性疾病、长期住院、抗生素治疗）。所有患者均在瑞典于默奥大学医院接受治疗。在住院期间，26例白血病患者中有14例出现出血情况。未发现特定部位。观察到出血与血小板计数低之间存在关联。在此期间，18例患者出现溃疡。溃疡主要出现在颊黏膜、嘴唇和舌部。在诱导治疗期间，注意到溃疡的数量和严重程度有增加的趋势。发现溃疡与粒细胞计数低之间存在关联。8例白血病患者出现念珠菌样改变。与白血病患者相比，参照组患者口腔黏膜病变的患病率较低。
