Department of Radiology, University of Cambridge, Cambridge, UK.
MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Kidney Int. 2020 Nov;98(5):1174-1178. doi: 10.1016/j.kint.2020.04.056. Epub 2020 Jun 22.
Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies to quantify the corticomedullary sodium gradient in healthy individuals and in a porcine model of diuresis. The results demonstrated that sodium MRI could detect spatial differences in sodium biodistribution across the kidney. The sodium gradient of the kidney changed significantly after diuresis in the pig model and was independent of blood electrolyte measurements. Thus, rapid sodium MRI can be used to dynamically quantify sodium biodistribution in the porcine and human kidney.
钠磁共振成像（MRI）是一种强大的、非侵入性技术，可用于评估肾脏内钠的分布。在这里，我们进行了临床前和临床研究，以定量评估健康个体和利尿猪模型的皮质-髓质钠梯度。结果表明，钠 MRI 可以检测到肾脏内钠生物分布的空间差异。在猪模型中利尿后，肾脏的钠梯度发生了显著变化，且与血液电解质测量无关。因此，快速钠 MRI 可用于动态定量评估猪和人肾脏中的钠生物分布。
