Gašić Uroš, Ćirić Ivanka, Pejčić Tomislav, Radenković Dejan, Djordjević Vladimir, Radulović Siniša, Tešić Živoslav
Department of Plant Physiology, Institute for Biological Research "Siniša Stanković", National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
Innovation Center, University of Belgrade-Faculty of Chemistry, P.O. Box 51, 11158 Belgrade, Serbia.
Antioxidants (Basel). 2020 Jun 23;9(6):547. doi: 10.3390/antiox9060547.
Pancreatic cancer (PC) is very aggressive and it is estimated that it kills nearly 50% of patients within the first six months. The lack of symptoms specific to this disease prevents early diagnosis and treatment. Today, gemcitabine alone or in combination with other cytostatic agents such as cisplatin (Cis), 5-fluorouracil (5-FU), irinotecan, capecitabine, or oxaliplatin (Oxa) is used in conventional therapy. Outgoing literature provides data on the use of polyphenols, biologically active compounds, in the treatment of pancreatic cancer and the prevention of acute pancreatitis. Therefore, the first part of this review gives a brief overview of the state of pancreatic disease as well as the procedures for its treatment. The second part provides a detailed overview of the research regarding the anticancer effects of both pure polyphenols and their plant extracts. The results regarding the antiproliferative, antimetastatic, as well as inhibitory effects of polyphenols against PC cell lines as well as the prevention of acute pancreatitis are presented in detail. Finally, particular emphasis is given to the polyphenolic profiles of apples, berries, cherries, sour cherries, and grapes, given the fact that these fruits are rich in polyphenols and anthocyanins. Polyphenolic profiles, the content of individual polyphenols, and their relationships are discussed. Based on this, significant data can be obtained regarding the amount of fruit that should be consumed daily to achieve a therapeutic effect.
胰腺癌（PC）极具侵袭性，据估计，近50%的患者在头六个月内死亡。这种疾病缺乏特异性症状，阻碍了早期诊断和治疗。如今，传统疗法使用吉西他滨单独或与其他细胞毒性药物联合使用，如顺铂（Cis）、5-氟尿嘧啶（5-FU）、伊立替康、卡培他滨或奥沙利铂（Oxa）。现有文献提供了关于多酚（生物活性化合物）在胰腺癌治疗和急性胰腺炎预防中的应用数据。因此，本综述的第一部分简要概述了胰腺疾病的状况及其治疗方法。第二部分详细概述了关于纯多酚及其植物提取物抗癌作用的研究。详细介绍了多酚对胰腺癌细胞系的抗增殖、抗转移以及抑制作用，以及对急性胰腺炎的预防作用。最后，鉴于苹果、浆果、樱桃、酸樱桃和葡萄富含多酚和花青素，特别强调了它们的多酚谱。讨论了多酚谱、单个多酚的含量及其相互关系。基于此，可以获得关于每日应食用多少水果才能达到治疗效果的重要数据。
