Reichel Michael P, Wahl Lloyd C, Ellis John T
Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, Hong Kong, China.
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Pathogens. 2020 Jun 23;9(6):505. doi: 10.3390/pathogens9060505.
has been recognised world-wide, first as a disease of dogs, then as an important cause of abortions in cattle for the past thirty years. Over that time period, there have been improvements in the diagnosis of infection and abortion, new tests have been developed and validated, and it is timely to review progress to date.
Bibliometric methods were used to identify major trends and research topics present in the published literature on . The tools used were SWIFT-Review, VOSviewer and SciMAT, along with the published papers found in the MEDLINE, Dimensions and Web of Science databases. A systematic review of the published literature ( = 2933) was also carried out via MEDLINE and systematically appraised for publications relevant to the pathogenesis, pathology and diagnosis of abortions.
A total of 92 publications were included in the final analysis and grouped into four main time periods. In these four different time periods, the main research themes were "dogs", "abortion", "seroprevalence" and "infection". Diagnostics, including PCR, dominated the first two time periods, with an increased focus on transmission and abortions, and its risk factors in cattle.
Longitudinal analyses indicated that the main themes were consistently investigated over the last 30 years through a wide range of studies, with evolving emphasis initially on dogs and diagnostic test development, followed by application to cattle, the identification of the risk factors leading to abortion, and in the latter time periods, an understanding of the immunity and a search for vaccines.
已在全球范围内得到认可，最初被认为是犬类疾病，在过去三十年中则被视为牛流产的重要原因。在此期间，感染和流产的诊断有了改进，开发并验证了新的检测方法，现在是时候回顾一下迄今为止的进展了。
采用文献计量学方法来确定已发表文献中关于[具体疾病名称未给出]的主要趋势和研究主题。使用的工具包括SWIFT-Review、VOSviewer和SciMAT，以及在MEDLINE、Dimensions和科学网数据库中找到的已发表论文。还通过MEDLINE对已发表的[相关疾病名称未给出]文献（n = 2933）进行了系统综述，并对与[相关疾病名称未给出]流产的发病机制、病理学和诊断相关的出版物进行了系统评估。
最终分析共纳入92篇出版物，并分为四个主要时间段。在这四个不同时间段，主要研究主题为“犬类”,“流产”，“血清阳性率”和“感染”。包括PCR在内的诊断方法在前两个时间段占主导地位，之后越来越关注传播、流产及其在牛中的风险因素。
纵向分析表明，在过去30年中，通过广泛的研究对主要主题进行了持续调查，最初重点是犬类和诊断测试的开发，随后应用于牛，确定导致流产的风险因素，在后几个时间段，则是对免疫的理解和寻找疫苗。
