Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.
Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Int J Mol Sci. 2020 Jun 23;21(12):4468. doi: 10.3390/ijms21124468.
Oral cancer is among the most common cancers worldwide and has become a major global health problem because of its relatively high morbidity and mortality rates. The sex-determining region on the Y-chromosome-related high-mobility-group box (SOX) transcription factor 11 (SOX11) plays a key role in human development and differentiation and is frequently increased in various human cancers. However, the clinical significance of SOX11 polymorphisms in oral cancer and their association with oral cancer risk are unclear. In this study, we included 1196 patients with oral cancer and 1200 controls. Real-time polymerase chain reaction was applied to analyze three SOX11 single-nucleotide polymorphisms (rs77996007, rs66465560, and rs68114586). Our results shown that SOX11 polymorphisms carriers with betel quid chewing were found to have an 8.38- to 9.23-fold risk to have oral cancer compared to SOX11 wild-type carriers without betel quid chewing. Furthermore, oral cancer patients who carried SOX11 rs77996007 "TC + CC" variants were significantly associated with large tumor size (AOR, 1.324; 95% CI, 1.047-1.674; = 0.019). Moreover, a database analysis using the Cancer Genome Atlas suggested that SOX11 mRNA expression was high during the tumor development process. In conclusion, our results suggest that SOX11 rs77996007 is involved in oral cancer progression and clinical characteristics.
口腔癌是全球最常见的癌症之一，由于其较高的发病率和死亡率，已成为一个主要的全球健康问题。Y 染色体相关高迁移率族盒转录因子 11（SOX11）位于性决定区，在人类发育和分化中起关键作用，在各种人类癌症中经常增加。然而，SOX11 多态性在口腔癌中的临床意义及其与口腔癌风险的关联尚不清楚。在这项研究中，我们纳入了 1196 例口腔癌患者和 1200 例对照。应用实时聚合酶链反应分析了三个 SOX11 单核苷酸多态性（rs77996007、rs66465560 和 rs68114586）。我们的结果表明，与未咀嚼槟榔的 SOX11 野生型携带者相比，咀嚼槟榔的 SOX11 多态性携带者患口腔癌的风险增加了 8.38 至 9.23 倍。此外，携带 SOX11 rs77996007“TC + CC”变异的口腔癌患者与大肿瘤大小显著相关（OR，1.324；95%CI，1.047-1.674；=0.019）。此外，使用癌症基因组图谱的数据库分析表明，SOX11 mRNA 表达在肿瘤发展过程中较高。总之，我们的结果表明 SOX11 rs77996007 参与了口腔癌的进展和临床特征。
