From Population Health Sciences (D.D.W., M.M.M., M.M.B., N.M., M.M.B.B.), German Center for Neurodegenerative Diseases; Department of Ophthalmology (M.M.M., R.P.F.) and Institute for Medical Biometry, Informatics and Epidemiology (M.M.B.B.), Faculty of Medicine, University of Bonn, Germany; and Department of Population Health Sciences (N.M.), School of Medicine and Public Health, University of Wisconsin-Madison.
Neurology. 2020 Sep 1;95(9):e1144-e1152. doi: 10.1212/WNL.0000000000010146. Epub 2020 Jun 25.
To quantify the associations of peripapillary retinal nerve fiber layer (pRNFL) thickness and macular ganglion cell layer (mGCL) volume with cognitive functioning and to investigate how demographic and vascular health factors affect these associations in a population-based sample of adults.
The sample included the first 3,000 participants (age range 30-95 years) of the Rhineland Study (recruited from March 2016 to December 2018) who underwent spectral-domain optical coherence tomography and cognitive assessment at 1 of 2 identical study centers in Bonn, Germany. We used multiple linear regression models to examine the relationships between retinal layer measurements and cognitive functioning after adjustment for confounders, and we examined the moderating effects of demographic and vascular health factors.
The analytical sample included 2,483 participants who were 54.3 years old (SD 13.8 years) on average. After full adjustment, each 1-SD decrease in mGCL volume was associated with a greater decrease in global function than that of pRNFL thickness (β = -0.048 [95% confidence interval (CI) -0.077 to -0.018] vs β = -0.021 [95% CI -0.049 to 0.007]). These relationships increased in strength with advancing age, were stronger in participants with hypertension, and were reversed in current smokers relative to nonsmokers.
mGCL volume is more strongly related to adult cognitive functioning than pRNFL thickness, making it a better potential biomarker of neurodegeneration. Age and vascular health factors play important roles in determining the strength and direction of this association.
量化视盘周围视网膜神经纤维层（pRNFL）厚度和黄斑神经节细胞层（mGCL）体积与认知功能的相关性，并研究人口统计学和血管健康因素如何影响这些相关性在基于人群的成年人样本中。
该样本包括 Rhineland 研究的前 3000 名参与者（年龄范围为 30-95 岁）（于 2016 年 3 月至 2018 年 12 月招募），他们在德国波恩的 2 个相同研究中心中的 1 个进行了光谱域光学相干断层扫描和认知评估。我们使用多元线性回归模型，在调整混杂因素后，检查视网膜层测量值与认知功能之间的关系，并检查人口统计学和血管健康因素的调节作用。
分析样本包括 2483 名参与者，他们的平均年龄为 54.3 岁（SD 13.8 岁）。在充分调整后，mGCL 体积每减少 1 个标准差，与 pRNFL 厚度相比，整体功能下降更大（β=-0.048[95%置信区间（CI）-0.077 至-0.018]比β=-0.021[95%CI-0.049 至 0.007]）。这些关系随着年龄的增长而增强，在高血压患者中更强，在当前吸烟者中相对于非吸烟者则相反。
mGCL 体积与成人认知功能的相关性强于 pRNFL 厚度，使其成为神经退行性变的更好潜在生物标志物。年龄和血管健康因素在确定这种相关性的强度和方向方面起着重要作用。
