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错失了以肺炎为后遗症诊断 HIV 的机会。

Missed opportunity to diagnose HIV with pneumonia as its sequela.

机构信息

Department of Acute Medicine, The Royal Berkshire Hospital, Reading, United Kingdom

Department of Acute Medicine, The Royal Berkshire Hospital, Reading, United Kingdom.

出版信息

BMJ Case Rep. 2020 Jun 24;13(6):e235386. doi: 10.1136/bcr-2020-235386.

DOI:10.1136/bcr-2020-235386
PMID:32587119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7319719/
Abstract

pneumonia (PCP) is an opportunistic infection of the lung occurring primarily in patients with HIV infection with a CD4 cell count <200 mm, solid organ transplant recipients and those taking immunosuppressive therapy. The 1980s heralded the HIV pandemic, turning PCP into a major medical and public health problem worldwide. Manifestations of unusual infections such as pneumocystis and Kaposi's sarcoma, were, after all, the first signs of the emerging pandemic to be recognised and may indeed, be the presenting feature of a previously undiagnosed HIV infection. With the advent of pneumocystis chemoprophylaxis and the initiation of highly active antiretroviral therapy, there has been a decreased incidence in developed countries, but it remains high in developing countries. Unfortunately, late presentation of HIV remains a problem resulting in significant morbidity and mortality. The authors report the case of a new diagnosis of HIV infection in a 45-year-old woman, presenting with a dry cough, dyspnoea, unintentional weight loss and PCP. Two weeks after commencing highly active antiretroviral therapy, she was diagnosed with immune reconstitution inflammatory syndrome. Research shows that stigma and discrimination in the healthcare setting contributes to keeping individuals from accessing HIV prevention, care and treatment services and adopting key preventive behaviours. The barriers to HIV testing and stigma eradication in primary care will be explored as well as missed opportunities to diagnosis HIV in primary care in individuals presenting with signs and symptoms of immunosuppression, in this case shingles.

摘要

卡氏肺孢子虫肺炎(PCP)是一种肺部机会性感染,主要发生在 CD4 细胞计数<200mm 的 HIV 感染患者、实体器官移植受者和接受免疫抑制治疗的患者中。20 世纪 80 年代,艾滋病大流行的出现使 PCP 成为全球范围内的一个主要医学和公共卫生问题。不常见感染(如卡氏肺孢子虫和卡波西肉瘤)的表现,毕竟是新兴大流行的最初迹象,并且可能确实是以前未确诊的 HIV 感染的表现特征。随着卡氏肺孢子虫化学预防和高效抗逆转录病毒治疗的出现,发达国家的发病率有所下降,但在发展中国家仍很高。不幸的是,HIV 的晚期出现仍然是一个问题,导致发病率和死亡率显著增加。作者报告了一例新诊断的 HIV 感染病例,一名 45 岁女性,表现为干咳、呼吸困难、非自愿性体重减轻和 PCP。开始高效抗逆转录病毒治疗两周后,她被诊断为免疫重建炎症综合征。研究表明,在医疗保健环境中的污名和歧视导致个人无法获得 HIV 预防、护理和治疗服务,并采取关键的预防行为。本文将探讨初级保健中 HIV 检测的障碍和污名的消除,以及在出现免疫抑制迹象和症状(本例为带状疱疹)的个体中,在初级保健中诊断 HIV 的机会丧失。