Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Central Sterile Supply Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.
Dis Markers. 2020 Jun 10;2020:4652483. doi: 10.1155/2020/4652483. eCollection 2020.
In this study, we investigated the utility of pentraxin 3 (PTX-3) in bronchoalveolar lavage fluid (BALF) as lung cancer (LCa) diagnostic. A total of 89 LCa patients and 84 non-LCa patients who received bronchoscopy in the First Affiliated Hospital of Xi'an Jiaotong University from December 2014 to February 2015 were enrolled. LCa was subdivided according to pathological type (scale, gland, and small cell lung cancer). BALF samples were obtained during bronchoscopy and PTX-3 levels assayed by ELISA. -tests, Mann-Whitney, and Kruskal-Wallis tests were performed for the comparison of PTX-3 levels between the different groups. Correlation analysis and receiver operating characteristic (ROC) analysis were used to analyze clinical data. The levels of PTX-3 increased in the LCa groups. PTX-3 levels were higher in the small cell lung cancer (SCLC) compared to non-small-cell lung cancer (NSCLC) groups. In LCa patients, obstructive pneumonia could upregulate the expression of PTX-3 in BALF. The area under the ROC curve of PTX-3 in BALF during LCa diagnosis, SCLC, and LCa with obstructive pneumonia was 0.949 ( ≤ 0.001), 0.672 ( < 0.05), and 0.838 ( < 0.01), respectively. In conclusion, PTX-3 in BALF has a potential value as an LCa biomarker, particularly in cases of SCLC and LCa with obstructive pneumonia.
在这项研究中，我们研究了五聚素 3（PTX-3）在支气管肺泡灌洗液（BALF）中的肺癌（LCa）诊断中的作用。2014 年 12 月至 2015 年 2 月，西安交通大学第一附属医院共纳入 89 例 LCa 患者和 84 例非 LCa 患者，接受支气管镜检查。根据病理类型（鳞癌、腺癌和小细胞肺癌）将 LCa 进一步细分。支气管镜检查时获取 BALF 样本，并通过 ELISA 测定 PTX-3 水平。采用 -检验、Mann-Whitney 和 Kruskal-Wallis 检验比较不同组之间的 PTX-3 水平。采用相关性分析和受试者工作特征（ROC）分析来分析临床数据。LCa 组的 PTX-3 水平升高。小细胞肺癌（SCLC）组的 PTX-3 水平高于非小细胞肺癌（NSCLC）组。在 LCa 患者中，阻塞性肺炎可上调 BALF 中 PTX-3 的表达。BALF 中 PTX-3 在 LCa 诊断、SCLC 和伴有阻塞性肺炎的 LCa 中的 ROC 曲线下面积分别为 0.949（≤0.001）、0.672（<0.05）和 0.838（<0.01）。总之，BALF 中的 PTX-3 作为 LCa 生物标志物具有潜在价值，特别是在 SCLC 和伴有阻塞性肺炎的 LCa 中。
