PTX3与泊沙康唑联合用药在大鼠侵袭性肺曲霉病模型中的疗效
Efficacy of PTX3 and posaconazole combination in a rat model of invasive pulmonary aspergillosis.
作者信息
Marra Emanuele, Sousa Vitor L, Gaziano Roberta, Pacello M Lucrezia, Arseni Brunilde, Aurisicchio Luigi, De Santis Rita, Salvatori Giovanni
机构信息
Takis srl, Rome, Italy
Areta International, Gerenzano, Italy.
出版信息
Antimicrob Agents Chemother. 2014 Oct;58(10):6284-6. doi: 10.1128/AAC.03038-14. Epub 2014 Jul 28.
Abstract
Posaconazole is currently used for the prophylaxis of invasive pulmonary aspergillosis (IPA). Limitations to posaconazole usage are drug-drug interactions and side effects. PTX3 is an innate immunity glycoprotein with opsonic activity, proven to be protective in IPA animal models. This study investigated the combination of posaconazole with PTX3. The results indicate synergy between PTX3 and posaconazole against aspergillosis, suggesting that a combination of reduced doses of posaconazole with the immune response enhancer PTX3 might represent a treatment option with a higher therapeutic index than posaconazole.
摘要
泊沙康唑目前用于预防侵袭性肺曲霉病（IPA）。泊沙康唑使用的局限性在于药物相互作用和副作用。PTX3是一种具有调理活性的天然免疫糖蛋白，已证实在IPA动物模型中具有保护作用。本研究调查了泊沙康唑与PTX3的联合应用。结果表明PTX3和泊沙康唑在抗曲霉病方面具有协同作用，这表明降低剂量的泊沙康唑与免疫反应增强剂PTX3联合使用可能是一种治疗选择，其治疗指数高于泊沙康唑。
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本文引用的文献
1
A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma.
Sensors (Basel). 2014 Jun 19;14(6):10864-75. doi: 10.3390/s140610864.
2
PTX3 as a paradigm for the interaction of pentraxins with the complement system.
Semin Immunol. 2013 Feb;25(1):79-85. doi: 10.1016/j.smim.2013.05.002. Epub 2013 Jun 6.
3
Effect of PTX3 and voriconazole combination in a rat model of invasive pulmonary aspergillosis.
Antimicrob Agents Chemother. 2012 Dec;56(12):6400-2. doi: 10.1128/AAC.01000-12. Epub 2012 Sep 24.
4
Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration.
Antimicrob Agents Chemother. 2012 Nov;56(11):5503-10. doi: 10.1128/AAC.00802-12. Epub 2012 Aug 13.
5
Lung transplant infection.
Respirology. 2013 Jan;18(1):22-38. doi: 10.1111/j.1440-1843.2012.02196.x.
6
The proteomic profile of circulating pentraxin 3 (PTX3) complex in sepsis demonstrates the interaction with azurocidin 1 and other components of neutrophil extracellular traps.
Mol Cell Proteomics. 2012 Jun;11(6):M111.015073. doi: 10.1074/mcp.M111.015073. Epub 2012 Jan 25.
7
Pathogen recognition by the long pentraxin PTX3.
J Biomed Biotechnol. 2011;2011:830421. doi: 10.1155/2011/830421. Epub 2011 Jun 2.
8
Efficacy of PTX3 in a rat model of invasive aspergillosis.
Antimicrob Agents Chemother. 2010 Oct;54(10):4513-5. doi: 10.1128/AAC.00674-10. Epub 2010 Jul 12.
9
Pulmonary aspergillosis: a clinical update.
QJM. 2007 Jun;100(6):317-34. doi: 10.1093/qjmed/hcm035.
10
The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps.
J Exp Med. 2007 Apr 16;204(4):793-804. doi: 10.1084/jem.20061301. Epub 2007 Mar 26.
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