Bakrim Saad, Motiaa Youssef, Ouarour Ali, Masrar Azlarab
Laboratory of Biology and Health, Abdelmalek Essaâdi University, Faculty of Science, BP 2121, Tetouan, Morocco.
Hematology Laboratory, Provincial Hospital Center, Mohammed VI Hospital, M'diq, Morocco.
Pan Afr Med J. 2018 Apr 9;29:205. doi: 10.11604/pamj.2018.29.205.13043. eCollection 2018.
Numerous biological parameters are physiologically modified during normal pregnancy, in particular hematology. The knowledge of these modifications of the maternal body by biologists and clinicians allows the screening of possible anomalies. In Morocco, the reference values of the complete blood count test for pregnant woman are missing, as are those specific to different trimesters of pregnancy. The aim of this study is to look for the reference values for healthy pregnant women of the Northwest region of Morocco, to compare them to those of non-pregnant women (control) and to those of the literature.
Blood samples were taken voluntarily from 3898 healthy pregnant women from 18 to 46 years old who presented themselves at the center of health Kalaa and at the service of gynecology obstetrics of the Provincial Hospital Center of M'diq (Morocco), for prenatal care. To establish the reference intervals of the CBC for non-pregnant women, a control group was constituted by 7035 healthy women from 18 to 50 years old selected according to the Moroccan law of blood donation. The CBC was measured on a Sysmex KX21N analyzer. For each sample a systematic blood smear was done to determine the leukocyte differential.
A statistically significant difference between the pregnant women and control group was noted (p < 0.05) for all the hematological parameters: red blood cells, hematocrit, hemoglobin, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, leukocytes, neutrophils, basophils, eosinophils, lymphocytes, monocytes, platelets and mean platelet volume. So, the comparison of the averages established between the first, second and third trimester of pregnancy showed the existence of a significant variation with regard to all the parameters of the CBC test looked for (p < 0.001).
The present study provides additional baseline data for basic hematological parameters in healthy pregnant Moroccan women and concluded that pregnancy in women has the tendency to alter some hematological indices. For these reasons, there is an interest to take these modifications into account for optimal maternal and fetal medical care.
在正常孕期，许多生物学参数会发生生理性改变，尤其是血液学参数。生物学家和临床医生了解母体的这些变化，有助于筛查可能存在的异常情况。在摩洛哥，缺乏孕妇全血细胞计数检查的参考值，以及孕期不同阶段的特异性参考值。本研究的目的是寻找摩洛哥西北地区健康孕妇的参考值，并将其与非孕妇（对照组）及文献中的参考值进行比较。
从3898名年龄在18至46岁、自愿到卡拉健康中心和穆迪格省医院中心妇产科进行产前检查的健康孕妇中采集血样。为确定非孕妇全血细胞计数的参考区间，根据摩洛哥献血法选取了7035名年龄在18至50岁的健康女性组成对照组。使用Sysmex KX21N分析仪测定全血细胞计数。对每个样本进行系统性血涂片以确定白细胞分类。
所有血液学参数（红细胞、血细胞比容、血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度、白细胞、中性粒细胞、嗜碱性粒细胞、嗜酸性粒细胞、淋巴细胞、单核细胞、血小板和平均血小板体积）在孕妇和对照组之间均存在统计学显著差异（p < 0.05）。因此，对孕期第一、第二和第三阶段确定的平均值进行比较表明，在所研究的全血细胞计数检查的所有参数方面均存在显著差异（p < 0.001）。
本研究为健康摩洛哥孕妇的基本血液学参数提供了额外的基线数据，并得出结论，女性怀孕往往会改变一些血液学指标。基于这些原因，考虑这些变化对于优化母婴医疗护理很有必要。
