Department of Dental Clinic, Federal University of Rio de Janeiro, RJ, Brazil.
Braz Oral Res. 2010 Oct-Dec;24(4):449-54. doi: 10.1590/s1806-83242010000400013.
Chronic kidney disease (CKD) is a debilitating systemic condition. Our working hypothesis is that CKD predialysis patients with periodontitis would respond poorly to periodontal treatment owing to immunologic compromise. Twenty-one predialysis patients (group 1) and 19 individuals without clinical evidence of kidney disease (group 2) with chronic periodontitis were subjected to non-surgical periodontal treatment with no antibiotics. Clinical periodontal and systemic parameters were evaluated at baseline and 3 months after treatment. Both groups showed significant and similar post-treatment improvements in all periodontal parameters examined. Most interestingly, periodontal treatment had a statistically significant positive effect on the glomerular filtration rate of each individual (group 1, p = 0.04; group 2, p = 0.002). Our results indicate that chronic periodontitis in predialysis kidney disease patients improved similarly in patients with chronic periodontitis and no history of CKD after receiving non-surgical periodontal therapy. This study demonstrates that CKD predialysis patients show a good response to non-surgical periodontal treatment.
慢性肾脏病（CKD）是一种使人虚弱的系统性疾病。我们的工作假设是，患有牙周炎的 CKD 透析前患者由于免疫功能受损，对牙周治疗的反应会较差。21 名透析前患者（第 1 组）和 19 名没有肾脏疾病临床证据的个体（第 2 组）患有慢性牙周炎，他们接受了无抗生素的非手术牙周治疗。在基线和治疗后 3 个月评估了临床牙周和系统参数。两组在接受治疗后所有检查的牙周参数均有显著且相似的改善。最有趣的是，牙周治疗对每位患者的肾小球滤过率都有统计学上的积极影响（第 1 组，p=0.04；第 2 组，p=0.002）。我们的结果表明，在接受非手术牙周治疗后，透析前慢性肾脏病患者的慢性牙周炎与无慢性肾脏病病史的患者的牙周炎改善情况相似。本研究表明，CKD 透析前患者对非手术牙周治疗有良好的反应。
