Niklasson Bo, Lindquist Lars, Klitz William, Englund Elisabet
Jordbro Primary Health Care Center, Stockholm, Sweden.
Department of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
J Alzheimers Dis Rep. 2020 May 20;4(1):141-146. doi: 10.3233/ADR-200174.
We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all AD cases but in none of the control specimens ( < 0.0001). The antibodies reacted with neurons and astrocytes and also showed distinct positive reaction in the amyloid/neuritic plaques. The possible role of an incompletely characterized picornavirus as the etiologic agent in AD open up the possibility of treatment with antiviral therapy directed against picornaviruses. The positive result of such treatment in a small number of patients is presented separately back to back to this report.
我们使用抗 Ljungan 病毒（LV）衣壳蛋白 1 的多克隆抗体，对 18 例阿尔茨海默病（AD）患者海马区的福尔马林固定尸检脑组织和 11 例年龄匹配的对照进行了研究。在所有 AD 病例中均发现了 LV 抗原的证据，但在对照标本中均未发现（<0.0001）。抗体与神经元和星形胶质细胞发生反应，并且在淀粉样蛋白/神经炎性斑块中也显示出明显的阳性反应。一种特征不完全明确的微小核糖核酸病毒作为 AD 的病原体的可能作用，为针对微小核糖核酸病毒的抗病毒治疗开辟了可能性。少数患者这种治疗的阳性结果将与本报告相继另行发表。
