Liu Nanyang, Jiang Xuefan, Li Hao
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Front Aging Neurosci. 2023 Mar 15;15:1129640. doi: 10.3389/fnagi.2023.1129640. eCollection 2023.
Increasing evidence highlights that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has long-term effects on cognitive function, which may cause neurodegenerative diseases like Alzheimer's disease (AD) in the future. We performed an analysis of a possible link between SARS-CoV-2 infection and AD risk and proposed several hypotheses for its possible mechanism, including systemic inflammation, neuroinflammation, vascular endothelial injury, direct viral infection, and abnormal amyloid precursor protein metabolism. The purpose of this review is to highlight the impact of infection with SASR-CoV-2 on the future risk of AD, to provide recommendations on medical strategies during the pandemic, and to propose strategies to address the risk of AD induced by SASR-CoV-2. We call for the establishment of a follow-up system for survivors to help researchers better understand the occurrence, natural history, and optimal management of SARS-CoV-2-related AD and prepare for the future.
越来越多的证据表明，感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）对认知功能有长期影响，未来可能会引发如阿尔茨海默病（AD）等神经退行性疾病。我们对SARS-CoV-2感染与AD风险之间的可能联系进行了分析，并提出了其可能机制的几种假设，包括全身炎症、神经炎症、血管内皮损伤、病毒直接感染以及淀粉样前体蛋白代谢异常。本综述的目的是强调感染SARS-CoV-2对未来AD风险的影响，提供大流行期间医疗策略的建议，并提出应对SARS-CoV-2诱发AD风险的策略。我们呼吁为幸存者建立随访系统，以帮助研究人员更好地了解SARS-CoV-2相关AD的发生、自然史和最佳管理方法，并为未来做好准备。
