Walsh Paul, Hankins Andrea, Bang Heejung
Department of Emergency Medicine, Sutter Medical Center Sacramento, 2825 Capitol Ave, Sacramento CA 95816.
Sutter Institute for Medical Research, 2825 Capitol Ave, Sacramento CA 95816.
medRxiv. 2020 Jun 12:2020.06.09.20123836. doi: 10.1101/2020.06.09.20123836.
Background CoVid-19 can be a life-threatening lung disease or a trivial upper respiratory infection depending on whether the alveoli are involved. Emergency department (ED) screening in symptomatic patients with normal vital signs is frequently limited to oro-nasopharyngeal swabs. We tested the null hypothesis that patients being screened for CoVid-19 in the ED with normal vital signs and without hypoxia would have a point-of-care lung ultrasound (LUS) consistent with CoVid-19 less than 2% of the time. Methods Subjects Subjects were identified from ED ultrasound logs. Inclusion criteria Age 14 years or older with symptoms prompting ED screening for CoVid-19. Exclusion criteria Known congestive heart failure or other chronic lung condition likely to cause excessive B lines on LUS. Intervention Structured blinded ultrasound review and chart review Analysis We used an exact hypothesis tests for binomial random variables. We also measured LUS diagnostic performance using computed tomography as the gold standard. Results We reviewed 77 charts; 62 met inclusion criteria. Vital signs were normal in 31 patients; 10 (32%) of these patients had LUS consistent with CoVid-19. We rejected the null hypothesis (p-value for bitest <0.001). The treating physicians' interpretation of their own point of care lung ultrasounds had a sensitivity of 100% (95% CI 75%, 100%) and specificity of 80% (95% CI 68%, 89%). Conclusion LUS has a meaningful detection rate for CoVid-19 in symptomatic emergency department patients with normal vital signs. We recommend at least LUS be used in addition to PCR testing when screening symptomatic ED patients for CoVid-19.
根据肺泡是否受累,新型冠状病毒肺炎(COVID-19)可以是一种危及生命的肺部疾病,也可以是一种轻微的上呼吸道感染。对生命体征正常的有症状患者在急诊科(ED)进行筛查时,通常仅限于口咽拭子检查。我们检验了一个零假设,即在急诊科对生命体征正常且无缺氧的COVID-19筛查患者进行即时床旁肺部超声(LUS)检查时,与COVID-19相符的情况出现的概率不到2%。
从急诊科超声记录中识别受试者。
年龄14岁及以上,有促使在急诊科进行COVID-19筛查的症状。
已知充血性心力衰竭或其他可能导致LUS上出现过多B线的慢性肺部疾病。
结构化盲法超声检查和病历审查
我们对二项式随机变量使用了精确假设检验。我们还以计算机断层扫描作为金标准来测量LUS的诊断性能。
我们审查了77份病历;62份符合纳入标准。31例患者生命体征正常;其中10例(32%)患者的LUS与COVID-19相符。我们拒绝了零假设(双样本检验的p值<0.001)。主治医生对其自身即时床旁肺部超声检查结果的解读敏感性为100%(95%置信区间75%,100%),特异性为80%(95%置信区间68%,89%)。
对于生命体征正常的有症状急诊科患者,LUS对COVID-19有显著的检出率。我们建议在对有症状的急诊科患者进行COVID-19筛查时,除了进行PCR检测外,至少还应使用LUS。