生活方式行为对衰弱发生率的影响。
The Influence of Lifestyle Behaviors on the Incidence of Frailty.
作者信息
Borda M G, Pérez-Zepeda M U, Samper-Ternent R, Gómez R C, Avila-Funes J A, Cano-Gutierrez C A
机构信息
M.U. Pérez-Zepeda MD, PhD, Geriatric Epidemiology Research Department, Instituto Nacional De Geriatría, Av. Contreras 428, Col. San Jerónimo Lídice, Del. La Magdalena Contreras, Ciudad de México C.P. 10200, ciudad de México, México, Phone +52 55 5655 1921, Email:
出版信息
J Frailty Aging. 2020;9(3):144-149. doi: 10.14283/jfa.2019.37.
BACKGROUND
Frailty is a clinical state defined as an increase in an individual's vulnerability to developing adverse health-related outcomes.
OBJECTIVES
We propose that healthy behaviors could lower the incidence of frailty. The aim is to describe the association between healthy behaviors (physical activity, vaccination, tobacco use, and cancer screening) and the incidence of frailty.
DESIGN
This is a secondary longitudinal analysis of the Mexican Health and Aging Study (MHAS) cohort.
SETTING
MHAS is a population-based cohort, of community-dwelling Mexican older adults. With five assessments currently available, for purposes of this work, 2012 and 2015 waves were used.
PARTICIPANTS
A total of 6,087 individuals 50-year or older were included.
MEASUREMENTS
Frailty was defined using a 39-item frailty index. Healthy behaviors were assessed with questions available in MHAS. Individuals without frailty in 2012 were followed-up three years in order to determine their frailty incidence, and its association with healthy behaviors. Multivariate logistic regression models were used to assess the odds of frailty occurring according to the four health-related behaviors mentioned above.
RESULTS
At baseline (2012), 55.2% of the subjects were male, the mean age was 62.2 (SD ± 8.5) years old. The overall incidence (2015) of frailty was 37.8%. Older adults physically active had a lower incidence of frailty (48.9% vs. 42.2%, p< 0.0001). Of the activities assessed in the adjusted multivariate models, physical activity was the only variable that was independently associated with a lower risk of frailty (odds ratio: 0.79, 95% confidence interval 0.71-0.88, p< 0.001).
CONCLUSIONS
Physically active older adults had a lower 3-year incidence of frailty even after adjusting for confounding variables. Increasing physical activity could therefore represent a strategy for reducing the incidence of frailty. Other so-called healthy behaviors were not associated with incident frailty, however there is still uncertainty on the interpretation of those results.
背景
衰弱是一种临床状态，定义为个体发生与健康相关不良后果的易感性增加。
目的
我们提出健康行为可降低衰弱的发生率。目的是描述健康行为（体育活动、疫苗接种、烟草使用和癌症筛查）与衰弱发生率之间的关联。
设计
这是对墨西哥健康与老龄化研究（MHAS）队列的二次纵向分析。
背景
MHAS是一个基于人群的队列，研究对象为居住在社区的墨西哥老年人。目前有五次评估，为开展本研究，使用了2012年和2015年的数据。
参与者
共纳入6087名50岁及以上的个体。
测量
使用39项衰弱指数定义衰弱。通过MHAS中的问题评估健康行为。对2012年无衰弱的个体进行三年随访，以确定其衰弱发生率及其与健康行为的关联。使用多因素逻辑回归模型评估根据上述四种与健康相关行为发生衰弱的几率。
结果
在基线（2012年）时，55.2%的受试者为男性，平均年龄为62.2（标准差±8.5）岁。衰弱的总体发生率（2015年）为37.8%。进行体育活动的老年人衰弱发生率较低（48.9%对42.2%，p<0.0001）。在调整后的多因素模型中评估的活动中，体育活动是唯一与较低衰弱风险独立相关的变量（比值比：0.79，95%置信区间0.71 - 0.88，p<0.001）。
结论
即使在调整混杂变量后，进行体育活动的老年人三年衰弱发生率仍较低。因此，增加体育活动可能是降低衰弱发生率的一种策略。然而，其他所谓的健康行为与衰弱发生无关，不过对这些结果的解释仍存在不确定性。
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