School of Environmental Science and Engineering, Xiamen University of Technology, Xiamen, Fujian, China.
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Rev Environ Health. 2020 Jun 25;35(4):461-470. doi: 10.1515/reveh-2020-0003. Print 2020 Nov 18.
The health risks brought by particles cannot be present via a sole parameter. Instead, the particulate matter oxidative potential (PM OP), which expresses combined redox properties of particles, is used as an integrated metric to assess associated hazards and particle-induced health effects. OP definition provides the capacity of PM toward target oxidation. The latest technologies of a cellular OP measurement has been growing in relevant studies. In this review, OP measurement techniques are focused on discussing along with PM characterization because of many related studies via OP measurements investigating relationship with human health. Many OP measurement methods, such as dithiothreitol (DTT), ascorbic acid (AA), glutathione (GSH) assay and other a cellular assays, are used to study the association between PM toxicity and PM characterization that make different responses, including PM components, size and sources. Briefly, AA and DTT assays are sensitive to metals (such as copper, manganese and iron etc.) and organics (quinones, VOCs and PAH). Measured OP have significant association with certain PM-related end points, for example, lung cancer, COPD and asthma. Literature has found that exposure to measured OP has higher risk ratios than sole PM mass, which may be containing the PM health-relevant fraction. PM characterization effect on health via OP measurement display a promising method.
颗粒带来的健康风险不能仅通过一个参数来体现。相反，颗粒的氧化潜力（PM OP）被用作一个综合指标，用于评估相关危害和颗粒引起的健康影响。OP 的定义提供了 PM 对目标氧化的能力。细胞 OP 测量的最新技术在相关研究中不断发展。在这篇综述中，OP 测量技术与 PM 特性一起进行讨论，因为许多相关研究通过 OP 测量来研究与人类健康的关系。许多 OP 测量方法，如二硫苏糖醇（DTT）、抗坏血酸（AA）、谷胱甘肽（GSH）测定和其他细胞测定，用于研究 PM 毒性与 PM 特性之间的关系，这些关系会产生不同的反应，包括 PM 成分、大小和来源。简而言之，AA 和 DTT 测定法对金属（如铜、锰和铁等）和有机物（醌、挥发性有机化合物和多环芳烃）敏感。测量的 OP 与某些与 PM 相关的终点显著相关，例如肺癌、COPD 和哮喘。文献发现，暴露于测量的 OP 比仅 PM 质量具有更高的风险比，这可能包含与 PM 健康相关的部分。通过 OP 测量 PM 特性对健康的影响显示出一种很有前途的方法。
