快照：Jak-STAT 信号转导 II。
SnapShot: Jak-STAT Signaling II.
机构信息
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
出版信息
Cell. 2020 Jun 25;181(7):1696-1696.e1. doi: 10.1016/j.cell.2020.04.052.
Abstract
The JAK-STAT pathway is an evolutionarily conserved signal transduction paradigm, providing mechanisms for rapid receptor-to-nucleus communication and transcription control. Discoveries in this field provided insights into primary immunodeficiencies, inherited autoimmune and autoinflammatory diseases, and hematologic and oncologic disorders, giving rise to a new class of drugs, JAK inhibitors (or Jakinibs).
摘要
JAK-STAT 通路是一种进化上保守的信号转导范例，为受体到细胞核的快速通讯和转录控制提供了机制。该领域的发现为原发性免疫缺陷、遗传性自身免疫和自身炎症性疾病以及血液学和肿瘤疾病提供了深入了解，并产生了一类新的药物，即 JAK 抑制剂（或 Jakinibs）。
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本文引用的文献
1
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J Immunol. 2020 Apr 15;204(8):2011-2020. doi: 10.4049/jimmunol.1901477.
2
The molecular details of cytokine signaling via the JAK/STAT pathway.JAK/STAT 通路介导的细胞因子信号转导的分子细节。
Protein Sci. 2018 Dec;27(12):1984-2009. doi: 10.1002/pro.3519.
3
USP18 - a multifunctional component in the interferon response.USP18-干扰素反应中的多功能组件。
Biosci Rep. 2018 Nov 15;38(6). doi: 10.1042/BSR20180250. Print 2018 Dec 21.
4
Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.细胞因子介导的人类淋巴细胞发育与功能调控：来自原发性免疫缺陷病的见解
J Immunol. 2017 Sep 15;199(6):1949-1958. doi: 10.4049/jimmunol.1700842.
5
Responses to Cytokines and Interferons that Depend upon JAKs and STATs.依赖 JAKs 和 STATs 的细胞因子和干扰素的反应。
Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1):a028555. doi: 10.1101/cshperspect.a028555.
6
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Cytokine. 2016 Nov;87:20-5. doi: 10.1016/j.cyto.2016.05.019. Epub 2016 Jun 3.
8
The JAK-STAT pathway at twenty.JAK-STAT 通路研究进展 20 年
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9
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10
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