Thomas V L, Sutton D N, Saunders D A
Shackleton Department of Anaesthetics, Southampton General Hospital.
Anaesthesia. 1988 Mar;43 Suppl:73-5. doi: 10.1111/j.1365-2044.1988.tb09077.x.
Fifty women of ASA grade 1 or 2 scheduled to undergo minor gynaecological procedures were allocated randomly to two groups. Group A received fentanyl 100 micrograms intravenously before induction; group B received no sedative or analgesic drugs. Anaesthesia was induced with propofol intravenously and maintained using 67% nitrous oxide in oxygen with incremental doses of propofol. Induction time and dose were significantly less and mean arterial pressure decreased significantly lower in Group A. These differences were, however, small and the ranges of values were large. The incidence of side effects and subjective assessment of quality of anaesthesia were similar in both groups. Fentanyl did not confer any practical advantage when used with propofol in the techniques described above.
五十名计划接受小型妇科手术的ASA 1或2级女性被随机分为两组。A组在诱导前静脉注射100微克芬太尼；B组未接受镇静或镇痛药物。静脉注射丙泊酚诱导麻醉，并使用67%的氧化亚氮和氧气混合气体，并递增丙泊酚剂量维持麻醉。A组的诱导时间和剂量明显更短，平均动脉压下降幅度明显更低。然而，这些差异很小，数值范围很大。两组的副作用发生率和麻醉质量主观评估相似。在上述技术中，芬太尼与丙泊酚合用时没有带来任何实际优势。
